Results 111 to 120 of about 3,562,122 (342)
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
Politics, Relief, and Reform: The Transformation of America's Social Welfare System during the New Deal [PDF]
The American social welfare system was transformed during the 1930s. Prior to the New Deal public relief was administered almost exclusively by local governments. The administration of local public relief was widely thought to be corrupt.
John Joseph Wallis +2 more
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FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
GENERAL ORIENTATIONS OF THE MANAGEMENT OF PUBLIC INSTITUTIONS IN THE CONTEXT OF THE KNOWLEDGE SOCIETY [PDF]
Romanian public administration and new public management are in need of a series of modernization actions resulted from theoretical progresses on European level whose application proved to have positive effects.
Adelina DUMITRESCU, Mihail DUMITRESCU
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Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Whither Public Interest: The Case of Greece's Public Finances [PDF]
During the last three decades there has been an almost continuous undermining of the public interest by private interests operating either outside or inside Greek public administration.
Christos Tsitsikas, Thomas Moutos
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FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Total quality management and public administration: the case of Vila Real town hall [PDF]
, 2005 The quality movement is based on a main idea: every good and service must have the maximum quality. To get to the bottom of this movement one has to understand in the first place the implications of its assumptions and how they reflect themselves upon ...
Brândao, Elísio (Coordinador) +3 more
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FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
RESCUING PUBLICNESS FROM ORGANIZATION STUDIES [PDF]
Does publicness still make sense as an issue for further research? Classic organizational sociology (or standard theory) has provided a breakthrough for understanding public administration and management, but has not fully explored the agenda. Publicness
Jean-Claude Thoenig
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