Results 121 to 130 of about 5,404,103 (319)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Nuevas especies altoandinas VII (Lepidoptera: Noctuidae)

Revista de Biología Tropical, 2001
Se describen cuatro nuevas especies en los géneros Scriptania Hampson (Hadeninae) (3 spp.) y Pseudoleucania Staudinger (1 sp.) (Noctuinae). Se describe la hembra y se da un nuevo registro geográfico para Scriptania lucens Köhler.
Marcela A. Rodríguez, Tania S. Olivares, Andrés O. Angulo   +2 more
doaj  

New records of some little known Australian polychaetous annelids [PDF]

, 1966
Olga Hartman
openalex   +1 more source

A new species of Alaocyba PERRIS, 1869 (Insecta : Coleoptera : Curculionidae : Raymondionyminae) from the Maltese Islands [PDF]

, 1998
A new species of Alaocyba PERRIS, 1869 is described from the Maltese Islands (Central Mediterranean). Alaocyba melitensis sp.n. is the first record of this tyrrhenian genus for Malta.
Magnano, Luigi, Mifsud, David
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Seven new species of Oncideres Lacordaire, 1830 (Coleoptera: Cerambycidae: Lamiinae: Onciderini) from South America, with notes on additional taxa

Arquivos de Zoologia, 2015
Seven new species of Oncideres Lacordaire, 1830 (Coleoptera: Cerambycidae: Lamiinae: Onciderini) are described and illustrated: Oncideres aliciae from French Guiana, Oncideres barclayi from French Guiana, Oncideres bezarki from Argentina, Oncideres ...
Eugenio H. Nearns, Gérard L. Tavakilian
doaj  

A new species and new record of the leaf-mining genus Dactylotula Cockerell (Lepidoptera: Gelechiidae) from China

, 2023
HUIDUO YANG, Kaijian Teng, Tengteng Liu
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The genus Phanerotomella Szépligeti (Insecta, Hymenoptera, Braconidae, Cheloninae) from China, with description of sixteen new species

European Journal of Taxonomy
The genus Phanerotomella Szépligeti, 1900 (Insecta, Hymenoptera, Braconidae, Cheloninae) is revised for China, including 42 species. A total of 16 new species are described: P. annulata sp. nov., P. atratoides sp. nov., P. aurantisoma sp.
Jia-Yue He, Cornelis Van Achterberg, Jun-Hua He, Pu Tang, Xue-Xin Chen   +4 more
doaj   +1 more source