Results 131 to 140 of about 3,887,035 (300)
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
New or interesting records of bryophytes from the Azores [PDF]
, 2005 Lepidozia stuhlmannii, L. pearsonii, Atrichum tenellum, Bryum lanatum, Campylopus subulatus, Ceratodon stenocarpus, Polytrichum commune var. humile and Thuidium delicatulum are reported as new to the Azores.
Frahm, Jan-Peter
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
New records of Laboulbeniales (Fungi, Ascomycota) for The Netherlands
, 2012 Laboulbeniales are obligate ectoparasitic ascomycetes occurring on Arthropoda, mostly insects. Since the 1950s almost no research on Laboulbeniales has been done in The Netherlands.
De Kesel, André +4 more
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Bryophytes of Rio Branco Municipality, Acre, Brazil [PDF]
, 1994 A survey of the bryophyte flora of Rio Branco Municipality, State of Acre, Brazil, has revealed a total of 76 species of bryophyte; 66 are new records for the State of Acre and two hepaticas, Cololejeunea dzumacensis P. Tix. and Lejeunea bermudiana (Evs.)
Visnadi, Sandra Regina +1 more
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FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Bryophytes of Uganda : 4., new and additional records, 2 [PDF]
, 2001 20 hepatics and 16 mosses are reported new to Uganda, 1 moss being also new to Africa.
Matcham, H. W. +3 more
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Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source