Results 51 to 60 of about 178,222 (302)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Revista Crítica de Ciências Sociais, 2008 Despite repeated evocations of the student struggles of the 1960s and 1970s, blanks and misunderstandings persist which lead to the presence of a too selective memory. This paper links the student movements of the time with the mutations which have since
Miguel Cardina
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Adult education and social movements : perspectives from Freire and beyond [PDF]
, 2012 The disenchantment with leftist, especially social democratic, parties in the West and elsewhere can easily lead to faith in social movements as organizations which apply pressure, combat co-optation (though not always) and are often perceived to provide
Mayo, Peter, English, Leona
core
Hacia una redefinición de los movimientos sociales: macro-actores proxémicos [PDF]
Athenea Digital, 2003 The aim of this paper is to propose a conceptualization of social movements that is not limited to the set of theories developed in the academic scope of new social movements; on the contrary, a different theoretical scenery will be suggested in order to
Mendiola, Ignacio
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
New Social Movements, the Use of ICTs, and Their Social Impact [PDF]
, 2016 El siguiente trabajo es el resultado una revisión sobre los Nuevos movimientos sociales y el uso de las nuevas tecnologías, vistos a la luz de la filosofía política.
Morador, Fernando Flores +3 more
core +1 more source
Annali di Ca’ Foscari: Serie Orientale, 2018 This contribution deals with issues related to the use of oral sources in historical research carried out during times marked by high political tensions and it focuses on the case of contemporary Turkey.
De Sanctis, Carlotta
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source