Results 31 to 40 of about 21,947,586 (290)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
ANOTHER TRADITIONAL ARCHITECTURE IN CANADA AND THE USA: EXPLORING SOME UNIQUE CONSTRUCTIVE TECHNIQUES [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2020 Generally, in the traditional architecture of Canada and the United States, wood has been used as the main and almost exclusive material for the construction of the buildings of early settlers as it was abundant in the area.
V. La Spina
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The new architecture of smart wheelchair system based on UM-BUS
Dianzi Jishu Yingyong, 2018 In this paper, according to the characteristics of reconfigurable high speed serial bus(UM-BUS), a new architecture of intelligent wheelchair system based on UM-BUS is proposed, which is superior to the traditional architecture in scalability and dynamic
Feng Shaohui, Zhu Xiaoyan, Zhang Weigong
doaj +1 more source
BETWEEN OLD AND NEW: REFLECTIONS OF TRADITIONAL ARCHITECTURAL ELEMENTS IN CONTEMPORARY ARCHITECTURE
INTERNATIONAL REFEREED JOURNAL OF DESIGN AND ARCHITECTUREAim: Architecture is a discipline that has evolved throughout history, constantly transforming in response to technological advances. This study analyzes the architectural continuity from the past to the present by examining the impact of traditional (historical) architectural elements on contemporary buildings.
Rojin YILDIZ +2 more
openaire +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Rethinking the traditional applied weaving practices in modern architecture
Архитектон, 2023 The article reviews international architectural experiences, which demonstrate a revival of interest in traditional and archetypally recognizable images in architecture.
Safonova Ekaterina V.
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source