Results 101 to 110 of about 2,549,913 (287)
SHS Web of Conferences, 2016 This paper is intended to help lay the groundwork for the formulation and design of programs and materials for environmental education focused on water issues and based on the perspective of the new water culture and ecosystem services.
Pérez José Gutiérrez +1 more
doaj +1 more source
Next Generation Microbiology Requirements [PDF]
, 2012 As humans continue to explore deep into space, microorganisms will travel with them. The primary means to mitigate the risk of infectious disease are a combination of prudent spacecraft design and rigorous operational controls. The effectiveness of these
Castro, V. A. +4 more
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
, 2011 A case in which colonial engineers and administrators, working in concert with engineers and officials based in Britain, sought to employ the "tools of empire" on the ...
John Broich
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Applied and Environmental MicrobiologyThe European Directive 2020/2184 concerning the quality of water for human consumption now includes Legionella among the pathogens for assessment in domestic water systems.
Maria Scaturro +67 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Six Collective Challenges for Sustainability of Almería Greenhouse Horticulture [PDF]
, 2019 Globally, current food consumption and trade are placing unprecedented demand on agricultural systems and increasing pressure on natural resources, requiring tradeoffs between food security and environmental impacts especially given the tension between ...
Alba Patiño, Daniela +19 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Area of reflection of longitudinal waves in multilayer Fibonacci arrangements
Results in Physics, 2018 In this article, we study the total reflection in 1D phonic crystals in quasiperiodic Fibonacci type arrangements of solid/solid layers. It was found that the reflection occurs in an area centered at a normalized frequency of 2π, and an angle of ...
L. Castro-Arce +3 more
doaj +1 more source