Results 51 to 60 of about 2,549,913 (287)

The African-American Intellectual of the 1920s: Some Sociological Implications of the Harlem Renaissance [PDF]

, 1996
This paper deals with some of the sociological implications of a major cultural high-water point in the African American experience, the New Negro/Harlem Renaissance.
Perry, Robert L., Peters, Melvin T.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Dairy farmers' responses to water quality interventions : a case study in the Manawatu-Wanganui region of New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Agriculture and Environment, Palmerston North, New Zealand [PDF]

, 2018
New Zealand freshwater quality has declined, and dairy farming is one identified contributor to this decline. This research provides insight into dairy farmers responses to the water quality interventions introduced to mitigate diffuse pollution, and the
Collins, Heather Mildred
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Endotoxin, a novel biomarker for the rapid risk assessment of faecal contamination of coastal and transitional waters

Journal of Water and Health
Current methods for testing water for faecal contamination rely on the culture of faecal indicator bacteria (FIB; Escherichia coli and Enterococci) that take 24–48 h, which leads to delays in taking proactive measures and poses a risk to public health ...
Christian R. Good, Alistair White, Joao Brandao, Simon Jackson   +3 more
doaj   +1 more source

Oxygen Content and its Diurnal Variation in a New Recirculanting Water Soilless Culture for Horticultural Crops [PDF]

HortScience, 2005
Based on a new structure for plastic culture channels, a new system for soilless culture called New Growing Systems (NGS) has been developed. It is similar to the nutrient film technique (NFT) but with several potential advantages. Each NGS growing channel has five plastic layers and a large number of holes, there is a dripper every 0.5 m above the ...
Miguel Urrestarazu, Pilar Carolina Mazuela, Abdelaziz Boukhalfa, Antonia Arán, María del Carmen Salas   +4 more
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Automated culture of aquatic model organisms: shrimp larvae husbandry for the needs of research and aquaculture

Animal, 2018
Modern research makes frequent use of animal models, that is, organisms raised and bred experimentally in order to help the understanding of biological and chemical processes affecting organisms or whole environments.
M. Mutalipassi, M. Di Natale, V. Mazzella, V. Zupo   +3 more
doaj   +1 more source

8th Britain-Nepal Academic Council Annual Lecture [PDF]

, 2010
Dr Rajendra Pradhan is currently Dean of Nepâ School of Social Sciences and Humanities and was a founding member and the Chair of Social Science Baha (January 2002 - June 2010).
Pradhan, Rajendra
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source