Results 131 to 140 of about 464,421 (291)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Proprioceptive derivation concept-Implications in dentistry
Journal of Indian Association of Public Health Dentistry, 2013 Dentists and dental students often assume awkward physical positions while providing treatment to (a) get a better view of the intraoral cavity; (b) provide a more comfortable position for the patient; and/or (c) operate equipment and reach for ...
Ajay Bhambhal +6 more
doaj
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Geographies of new ways of working
Applied GeographyGrzegorz Micek +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
PRECONDITIONS OF INTRODUCTION OF COMPUTER-ORIENTED MEANS OF EDUCATION IN PEDAGOGICAL COLLEGES
Інформаційні технології і засоби навчання, 2010 The topical issues of introduction of means of information-communication technologies in the process of teacher training in pedagogical college with use of essentially new ways of informative activity are considered.
Olga M. Naumenko, Hryhorii H. Naumenko
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Connections: New Ways of Working in the Networked Organization
, 1991 L. Sproull, Sara B. Kiesler
semanticscholar +1 more source