Results 81 to 90 of about 10,800,210 (238)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
British Journal of General Practice, 2014 In a few months’ time the UK will have a new government. That much is certain, but the political, economic, and medical landscape beyond May 2015 is anything but. In the meantime the health service has become a political football as never before. Bidding wars rage over the number of new GPs that the parties will produce; by magic, of course, for where ...
openaire +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
New year, new advice, new news
Revista Brasileira de Ortopedia (English Edition), 2010 We start another year with this issue of the RBO, which now contains a greater number of studies. This was decided by the Editorial Board and the new directorate of the SBOT, in view of the ever greater number of studies sent for publication: instead of more issues, a journal with a greater number of studies.
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
BMJ, 2004 New Year's Day is nothing but an arbitrary day that, for instance, was celebrated by the Babylonians at the new moon after the spring equinox (and next year, the 1 Nisanu 2631 will be on what we call 9 April 2005 (www.cf-software.com/other.html)). On 1 January no check, no pause, no planetary escapement in the celestial clockwork will take place as our
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Migration Fuels a Second Year of Higher Population Gain in New Hampshire [PDF]
, 2019 In this data snapshot, author Kenneth Johnson reports that the population of New Hampshire grew by 6,700 between July of 2017 and July of 2018 to 1,356,000 according to new Census Bureau estimates.
Johnson, Kenneth M.
core +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Inflammatory Activity on Natalizumab Predicts Short-term but not Long-term Disability in Multiple Sclerosis [PDF]
, 2017 BACKGROUND: In people with multiple sclerosis treated with interferon-beta or glatiramer acetate, new MRI lesions and relapses during the first year of treatment predict a poor prognosis.
Dahdaleh, S +5 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source