Results 131 to 140 of about 19,003,674 (294)
Advanced Science, EarlyView.Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng +15 more
wiley +1 more source
Journal of the New York Botanical Garden
, 1941 Vols. for 1933-1941, 1945 include the Annual report of the director, 1933-1940, 1944 (previously published in its Bulletin). Indexes: Vols. 1-15, 1900-1914, issued as v. 15, no. 180; Vols. 16-30, 1915-1929, issued as v. 30, no. 360.
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The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
Relief shown by hachures. Covers Southeastern portion of New York and parts of Connecticut from the Massachusetts state line to Scarsdale, New York. At head of title: No.
New York (State)
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Advanced Science, EarlyView.PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao +8 more
wiley +1 more source
Correction: Naming convention for gradient system transfer function and gradient system frequency response for magnetic resonance imaging encoding field characterization. [PDF]
MAGMAWehkamp N +6 more
europepmc +1 more source
Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning
Advanced Science, EarlyView.Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu +6 more
wiley +1 more source
Advanced Science, EarlyView.Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu +20 more
wiley +1 more source
Journal of the New York Botanical Garden
, 1929 Greenhouse Suggestions for the Amateur; Observations on a Shot-hole Disease and Insect Pests of the Japanese Cherries; Franklin Sumner Earle; Earle's Sugar Cane and Its Culture 88; A Gladiolus Society being Organized for New York City; Publications of ...
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