Results 51 to 60 of about 332,419 (262)

Early‐phase amyloid PET reproduces metabolic signatures of cognitive decline in Parkinson's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Recent work suggests that amyloid beta (Aβ) positron emission tomography (PET) tracer uptake shortly after injection (“early phase”) reflects brain metabolism and perfusion.
William W. T. Aye, Megan R. Stark, Kyla‐Louise Horne, Leslie Livingston, Sophie Grenfell, Daniel J. Myall, Toni L. Pitcher, Mustafa M. Almuqbel, Ross J. Keenan, Wassilios G. Meissner, John C. Dalrymple‐Alford, Tim J. Anderson, Campbell Le Heron, Tracy R. Melzer   +13 more
doaj   +1 more source

Protocol for the INFORM ASTHMA Trial: budesonide–formoterol reliever in adults with asthma on maintenance inhaled corticosteroid

ERJ Open Research
Background International asthma guidelines recommend inhaled corticosteroid (ICS)/formoterol in preference to short-acting β2-agonist (SABA) reliever-based regimens as reliever therapy in adults and adolescents of all asthma severities.
Jonathan Noble, Orlagh Bean, Pepa Bruce, Melissa Black, Ross Sayers, Ryan Cullen, Bianca Black, Mark Holliday, Louis Kirton, Blake Perry, Allie Eathorne, Ian Pavord, Mark Weatherall, Richard Beasley   +13 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Can public-private partnerships drive transformational climate adaptation? Seafood sector pathways in Aotearoa New Zealand

Environmental Research Letters
Transformational climate adaptation requires coordinated action across sectors and scales, enabled by governance arrangements that can address systemic barriers.
James R A Butler, Nicholas A Cradock-Henry, Erik Behrens, Romain Chaput, Katie M Cook, Vonda J Cummings, Ian Davidson, Jessica A Ericson, Leigh M Howarth, Ben Knight, Carolyn Lundquist, Rob Major, Richard L O’Driscoll, Darren M Parsons, Norman L C Ragg, Jane E Symonds   +15 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Medium-Dose Compared With High-Dose Inhaled Corticosteroids in Combination Triple Inhaler Therapy for Asthma

CHEST Pulmonary
Background: Combination inhaled corticosteroid (ICS)/long-acting beta 2 -agonist (LABA)/long-acting muscarinic antagonist (LAMA) triple therapy is used in severe asthma.
Samantha Warhurst, PhD, Ryan Cullen, MBChB, Ross Sayers, MBBS, Francesca Lynch, Joseph Kulathinal, BSc, Mark Weatherall, FRACP, Richard W. Beasley, DSc, Jonathan H. Noble, MBBS   +7 more
doaj   +1 more source

Phase‐Resolved Dual Control of Phenol Photodissociation at the Air–Water Interface From Structure‐Resolved Statistics

Advanced Science, EarlyView.
Faster phenol photolysis at the air–water interface arises from two cooperative factors: a more favorable initial microenvironment for solvent‐side electron stabilization, which lowers CI access, and a more labile hydrogen‐bond network, which more readily reorganizes to stabilize the dark‐state intermediate.
Qiang Yin, Jialing Shi, Jinping Zhao, Chengjun Li, Yongbo Xie, Benkun Tan, Da Wang, Ziyun Wang, Yu Mao   +8 more
wiley   +1 more source

Test-retest reliability and sample size estimates after MRI scanner relocation

NeuroImage, 2020
Objective: Many factors can contribute to the reliability and robustness of MRI-derived metrics. In this study, we assessed the reliability and reproducibility of three MRI modalities after an MRI scanner was relocated to a new hospital facility. Methods:
Tracy R. Melzer, Ross J. Keenan, Gareth J. Leeper, Stephen Kingston-Smith, Simon A. Felton, Sarah K. Green, Kerry J. Henderson, Nickolas J. Palmer, Reza Shoorangiz, Mustafa M. Almuqbel, Daniel J. Myall   +10 more
doaj   +1 more source

Asthma in New Zealand [PDF]

BMJ, 1983
not be forthcoming from anywhere else. Politically it sometimes seems to be under a cloud because of doubtful ethics in the advertising and selling of their products. Sometimes there is criticism of the profits they make. Yet the industry is responsible for most of the major therapeutic advances in medicine.
openaire   +2 more sources

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source