Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Advanced Science, EarlyView.Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen +19 more
wiley +1 more source
Successful Treatment of Actinic Keratosis with Kanuka Honey
Case Reports in Dermatological Medicine, 2018 Actinic keratoses form as rough, scaly plaques on sun-exposed areas; they can be an important step in premalignant progression to squamous cell cancer of the skin. Currently, pharmacological treatments consist of topical immunomodulatory agents with poor
Saras Mane +3 more
doaj +1 more source
Designated auditing agency handbook: Ministry of Health auditor handbook (revised 2015) [PDF]
Introduction: This handbook outlines the Ministry of Health\u27s requirements of designated auditing agencies for auditing and audit reporting for the certification of health care services under the Health and Disability Services (Safety) Act 2001.
Ministry of Health (New Zealand)
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Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Challenge of New Zealand Greenshell™ mussel Perna canaliculus larvae using two Vibrio pathogens: a hatchery study [PDF]
, 2009 Aditya Kesarcodi-Watson +3 more
openalex +1 more source
Monthly economic review - May 2015 [PDF]
The Monthly Economic Review is an overview of the New Zealand economy. It includes the latest data on New Zealand’s economic growth, unemployment, inflation, merchandise trade and balance of payments figures, along with certain financial data (such as ...
Parliamentary Library (New Zealand)
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New Zealand foreign policy under the Clark government: High tide of liberal internationalism [PDF]
, 2005 The foreign policy of the current New Zealand government has strongly reflected the Labour Party’s Liberal Internationalist ideology. Indeed, it is probable that this government has been the most Liberal Internationalist of all New Zealand Labour ...
McCraw, David
core +2 more sources
Advanced Science, EarlyView.This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen +4 more
wiley +1 more source
Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation
Advanced Science, EarlyView.A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun +8 more
wiley +1 more source
Associated Factors of Drinking Prior to Recognising Pregnancy and Risky Drinking among New Zealand Women Aged 18 to 35 Years [PDF]
, 2019 Sherly Parackal +2 more
openalex +1 more source