Results 201 to 210 of about 1,922,511 (410)

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

A MXene‐Based Nanothermal Knife Inhibits Aggresome‐Mediated Persister Formation for Preventing Dental Caries

Advanced Science, EarlyView.
Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang, Leilei Yang, Jing jiao, Wenshuai Li, Sen Lin, Xianlong Zong, Haoyang Qin, Danfeng Liu, Rui Li   +8 more
wiley   +1 more source

Prevalence of permanent childhood hearing impairment in the United Kingdom and implications for universal neonatal hearing screening: questionnaire based ascertainment study Commentary: Universal newborn hearing screening: implications for coordinating and developing services for deaf and hearing impaired children [PDF]

, 2001
Heather Fortnum, A. Quentin Summerfield, David H. Marshall, Adrian Davis, John Bamford, Adrian Davis, C. Yoshinaga-Itano, Sally Hind   +7 more
openalex   +1 more source

A NEW OUTCOME MEASURE FOR COST-UTILITY ANALYSES OF SCREENING PROGRAMS [PDF]

In this paper we provide a new outcome measure for the cost-utility analyses of alternative screening programs of a particular disease. We show that for non-invasive screening programs satisfying plausible assumptions, QALYs can be replaced by a simpler ...
Carmen Herrero Blanco, Juan D. Moreno Ternero   +1 more
core  

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

Advanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen, Li Gong, Wei Yang, Jiaqi Luo, Zhen Jin, Youzhi Tang   +5 more
wiley   +1 more source

Genetic counseling after implementation of statewide cystic fibrosis newborn screening: Two years' experience in one medical center [PDF]

, 2001
Patricia G. Wheeler, Rosemarie Smith, Henry L. Dorkin, Richard B. Parad, Anne Marie Comeau, Diana W. Bianchi   +5 more
openalex   +1 more source

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

Advanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su   +7 more
wiley   +1 more source

Genetic analyses of very long-chain acyl-coenzyme A dehydrogenase deficiency: A case report with a novel ACADVL variant

Molecular Genetics and Metabolism Reports
Background: Very long-chain acyl-coenzyme A dehydrogenase deficiency (VLCADD) is a rare autosomal recessive disease associated with variants in the ACADVL gene.
Wei Zhou, Huizhong Li, Li Yang
doaj  

Molecular characterisation of 34 patients with biotinidase deficiency ascertained by newborn screening and family investigation [PDF]

, 2001
Adolf Mühl, Dorothea Möslinger, Chike Bellarmine Item, Silvia Stöckler-Ipsiroglu   +3 more
openalex   +1 more source

Implementation of population-based newborn screening reveals low incidence of spinal muscular atrophy

Genetics in Medicine, 2020
Denise M. Kay, C. Stevens, A. Parker, Carlos A. Saavedra-Matiz, Virginia Sack, W. Chung, C. Chiriboga, Kristin E. Engelstad, E. Laureta, O. Farooq, E. Ciafaloni, B. Lee, Sohail Malek, Simona O. Treidler, Y. Anziska, Leslie Delfiner, Ai Sakonju, M. Caggana   +17 more
semanticscholar   +1 more source