Results 221 to 230 of about 212,548 (293)

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

Screening for Life: Perspectives From Adult Metabolic Specialists on Newborn Screening for Inherited Metabolic Diseases. [PDF]

J Inherit Metab Dis
Langeveld M, Sirrs S, Schoenmakers DH, Fazio T, van der Klauw MM, Maillot F, Sharma R, Tran C, Ziagaki A, Mochel F.   +9 more
europepmc   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

Advanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang, Wenye Wang, Yidong Peng, Weiji Weng, Hanyu Wei, Qiyuan Feng, Antian Wang, Minjie Hu, Zhuoran Li, Shenyu Sun, Zhenghui He, Daiwen Zhang, Wenlan Qi, Yuhan Han, Zixuan Ma, Jiyuan Hui, Ru Gong, Yingwei Gao, Yong Lin, Jiyao Jiang, Xiaoling Gao, Junfeng Feng   +21 more
wiley   +1 more source

Alpha+ Thalassemia in Northwestern Tanzania: Molecular and Hematological Insights From Newborn Screening. [PDF]

J Blood Med
Ambrose EE, Kidenya BR, Smart LR, Manjurano A.   +3 more
europepmc   +1 more source

Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration

Advanced Science, EarlyView.
Centimeter‐scale tendon organoids are engineered by mimicking the extracellular matrix and optimizing chemical cues to guide tendon stem/progenitor cells. These large, self‐assembling constructs overcome conventional size limitations and exhibit enhanced tenogenic differentiation, extracellular matrix production, and mechanical resilience. Their tissue‐
Tianshun Fang, Hong Zhang, Yuanhao Xie, Xiongfeng Li, Xi Liu, Zichen Wang, Yiwen Xue, Xiaohui Xia, Zetao Wang, Tingyun Lei, Ruifu Lin, Weiliang Shen, Bingbing Wu, Yishan Chen, Yanan Du, Xiao Chen, Zi Yin   +16 more
wiley   +1 more source

Newborn screening and the screening laboratory: past, present and future. [PDF]

Eur Thyroid J
Boelen A, Heijboer AC.
europepmc   +1 more source

Hinst: Human‐Like Interactive Instinct Enables Robots to Robustly Accomplish Universal Tasks

Advanced Science, EarlyView.
Aiming at current robot limitations of poor flexibility, poor practicality, and poor universality in task accomplishment, the authors report a human‐like interactive instinct (Hinst) and an anthropomorphic robotic system architecture. The Hinst greatly enhances the efficiency and the success rate of robotic manipulation, skill learning, and task ...
Zijian Liao, Qian Mao, Yichen Qin, Jinfeng Yuan, Rong Zhu   +4 more
wiley   +1 more source

Spinal muscular atrophy in the era of newborn screening: how the classification could change. [PDF]

Front Neurol
Varone A, Esposito G, Bitetti I.
europepmc   +1 more source

Electrochemistry as a Tool for Redox‐Based Bio‐Information Processing

Advanced Science, EarlyView.
Redox is a modality that is native to biology and accessible to electronics through electrochemistry. Imposed electronic inputs are transduced into redox signals that can probe for bio‐information or actuate biological responses. Measured electronic output responses are analyzed to reveal actionable information.
Eunkyoung Kim, Chen‐yu Chen, Fauziah Rahma Zakaria, Dana Motabar, Mijeong Kang, Deanna L. Kelly, Alessandra Napolitano, William E. Bentley, Gregory F. Payne   +8 more
wiley   +1 more source