Results 231 to 240 of about 849,858 (379)

Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage

Advanced Science, EarlyView.
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang, Ruiying Qiang, Yuan Zhang, Jinxian Wan, Chen Tao, Ying Dong, Xujun Tang, Li Xu, Hairong Xiao, Yanqin Lin, Wei Tong, Ying Ma, Yongming Wang, Peng Li, Renjie Chai   +14 more
wiley   +1 more source

21-deoxycortisol as a second-tier test in congenital adrenal hyperplasia newborn screening in The Netherlands: two-year evaluation. [PDF]

Arch Dis Child
Olthof A, Bouva MJ, Claahsen-van der Grinten HL, Westra D, Dekkers E, Heijboer AC, Hannema SE, Boelen A.   +7 more
europepmc   +1 more source

Body Perception in Newborns [PDF]

, 2013
Maria Laura Filippetti, Mark H. Johnson, Sarah Lloyd‐Fox, Danica Dragovic, Teresa Farroni   +4 more
openalex   +1 more source

Fragility of epidermis in newborns, children and adolescents

Journal of the European Academy of Dermatology and Venereology, 2016
U. Blume-Peytavi, Jerry Tan, D. Tennstedt, F. Boralevi, G. Fabbrocini, A. Torrelo, R. Soares-Oliveira, M. Haftek, A. Rossi, M. Thouvenin, J. Mangold, M. Galliano, H. Hernandez-Pigeon, M. Aries, C. Rouvrais, S. Bessou-Touya, H. Duplan, N. Castex‐Rizzi, V. Mengeaud, P. Ferret, E. Clouet, M. S. Aroman, C. Carrasco, C. Coutanceau, B. Guiraud, S. Boyal, A. Herman, H. Delga, Krysta Biniek, R. Dauskardt   +29 more
semanticscholar   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Acute and Long-Term Healthcare Utilization and Expenditures for Serious Bacterial Infections among Newborns in US Hospitals. [PDF]

Infect Dis Ther
Noble KN, Schley K, Abramovitz L, Willis SJ, Hayford K, Moisi JC, Weycker D.   +6 more
europepmc   +1 more source

Distinct DNA methylomes of newborns and centenarians

Proceedings of the National Academy of Sciences of the United States of America, 2012
H. Heyn, Ning Li, H. J. Ferreira, S. Moran, D. Pisano, A. Gómez, Javier Díez, J. Sanchez-Mut, F. Setién, F. Carmona, A. Puca, Sergi Sayols, M. Pujana, J. Serra-Musach, Isabel Iglesias-Platas, F. Formiga, A. Fernández, M. Fraga, M. Fraga, S. Heath, A. Valencia, I. Gut, Jun Wang, Jun Wang, M. Esteller   +24 more
semanticscholar   +1 more source

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source

Aortic arch reconstruction in newborns with an autologous pericardial patch: contemporary results [PDF]

, 2012
Massimo Bernabei, Rafik Margaryan, Luigi Arcieri, Giacomo Bianchi, Vitali Pak, Bruno Murzi   +5 more
openalex   +1 more source

Early Weight Loss Nomograms for Exclusively Breastfed Newborns

Pediatrics, 2015
V. Flaherman, Eric W. Schaefer, Michael W. Kuzniewicz, Sherian Li, Eileen M. Walsh, I. Paul   +5 more
semanticscholar   +1 more source