Results 131 to 140 of about 348,334 (245)

Sepsis, Patient Monitoring and Nursing Research. [PDF]

J Multidiscip Healthc
Jordan S.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Hop (Humulus lupulus L.) Phytochemical Profiles as a Function of Growth Region by HPLC and GC-MS Analysis

ACS Omega
Celina Paoletta, Christopher Balog, Andrew Higgs, Dmitry Liskin, Abigail Brehm, Kevin Kingsbury, Ronald A. Quinlan   +6 more
doaj   +1 more source

The Medicine Quality Monitoring Globe: A public health intelligence system for collecting and curating reports of substandard and falsified medical products from publicly available Internet news media. [PDF]

PLOS Digit Health
Freifeld CC, Van Assche K, Olliaro A, Battain M, Kitignavong I, Vidhamaly V, Boupha P, Boutsamay K, Thi Do N, Bellingham K, Pimxayvong V, Olinh T, Rosado Olmo A, Xu J, Jiang S, Soult A, Insal S, Guérin PJ, Newton PN, Caillet C.   +19 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Linguistic markers of deception in Arabic news headlines: A cross-corpus study of stylistic and numeric features. [PDF]

PLoS One
Albtoush ES, Gan KH, Alrababah SAA.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Navigating the Conversation: How Can the News Media Responsibly Communicate Drug Use to the Australian Community? [PDF]

Drug Alcohol Rev
Kershaw S, Valentish J, Nagle J, Paton E, Stockings E, Chapman C.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mortality risk ranking after medical emergency team review: External validation and redevelopment of predictive models. [PDF]

Crit Care Resusc
Batterbury A, Conway A, Mattiussi M, Geary A, Douglas C.   +4 more
europepmc   +1 more source