Results 81 to 90 of about 3,252,482 (283)

Disinformation and Fact-Checking in the Face of Natural Disasters: A Case Study on Turkey–Syria Earthquakes

Societies
Natural disasters linked to contexts of unpredictability and surprise generate a climate of uncertainty in the population, resulting in an exponential increase in disinformation.
Sandra Méndez-Muros, Marián Alonso-González, Concha Pérez-Curiel   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Haber Ajansları Tarafından Geliştirilen Gazetecilikte Yapay Zekâ Kullanımı Standartları

İletişim Kuram ve Araştırma Dergisi
Bu çalışmada, yapay zekâ uygulamalarının, habercilerin gündelik pratiklerinde kullanımının beraberinde taşıdığı sorumluluklar üzerine, dünyanın önde gelen haber ajanslarının geliştirmeye çalıştıkları standartlar incelenmiştir.
Ayça Gökdemir
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Practicing Media—Mediating Practice | Reporting, Uncertainty, and the Orchestrated Fog of War: A Practice-Based Lens for Understanding Global Media Events

International Journal of Communication, 2020
Media coverage of the ongoing multistate conflict in Syria, extending into Iraq, has been punctuated by the marshaling of conditions for exceptional global media event coverage by states, citizens, and newsmakers alike.
Kenzie Burchell
doaj  

The challenges faced by the international news agencies AFP, Reuters, AP and Bloomberg in the era of GAFAM and Artificial Intelligence

, 2022
Today, international news agencies are faced with an ever-changing technological landscape and pace of production to which they must adapt. They must also balance the loss of revenue, the loss of audience loyalty, and the competition they face from ...
Martinez-Mendez, Paloma, White, Patrick
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

From Headlines to Thumbnails: Comparative Analysis of Web Publications in Bulgarian Digital Media and YouTube

Journalism and Media
The objective of this study is to determine if the thematic priorities of news organizations are consistent or platform-specific by investigating the cross-platform strategies of three leading Bulgarian news agencies. Methodologically, the study combines
Plamen Hristov Milev, Yavor Nikolov Tabov   +1 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source