Results 61 to 70 of about 1,136 (248)

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Media ensembles in depopulating municipalities and news deserts: insights from Castilla-La Mancha, Spain

Social Sciences and Humanities Open
This study analyzes the role of media ensembles in municipalities at risk of depopulation in Castilla-La Mancha, Spain, exploring their function as communicative resilience resources in areas classified as news deserts.
Francisco Javier Rueda-Córdoba, Vanesa Sáiz-Echezarreta, Belén Galletero-Campos   +2 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Local Media, Rural Depopulation, and Territorial Attachment: Geographies of Hope in Castilla-La Mancha

Media and Communication
This article explores the relationship between local media ecosystems and territorial hope in depopulated rural areas of Castilla-La Mancha (Spain).
Vanesa Saiz-Echezarreta, Belén Galletero-Campos, Joan Ramon Rodriguez-Amat   +2 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Exploring the Visibility Gap Between Public Investment and Media Discourse in the Wrocław Participatory Budget

Applied Sciences
The purpose of this paper is to analyze the media visibility of investments implemented in Wrocław, with a particular focus on the democratization of urban processes through the Wrocław Participatory Budget (WPB) and to study the public perception of ...
Patryk Mierzejewski, Klaudiusz Tomczyk, Grzegorz Chrobak, Iwona Kaczmarek   +3 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Especificidades regionais no debate sobre jornalismo e engajamento climático

Sur le Journalisme
PT. O jornalismo é uma das principais arenas de enfrentamento da crise climática por seu comprometimento com o interesse público e pela veiculação de informações que baseiam decisões cotidianas dos sujeitos.
Eloisa Beling Loose, Ilza Maria Tourinho Girardi, Débora Gallas Steigleder   +2 more
doaj   +1 more source