Results 111 to 120 of about 2,169,062 (297)
, 1984 This item contains six issues of the Take One newsletter: March 2, 4, 5, 15, 16, and 29, 1984Take One was published every two weeks and focused on short news items and announcements "for the people of University Hospital.
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Risk and RAPA on the Internet [PDF]
, 1995 Editorial news item announcing new email addresses and electronic formats for back issues and indexes. Details on an upcoming conference entitled Promoting and Managing Genome Innovation scheduled to be held October 13-14, 1995 are also ...
Field, Thomas G., Jr.
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Journalism and MediaDisadvantaged groups often face negative portrayals in the media, particularly in news outlets. These portrayals lead to misrepresentation, misunderstanding, and perpetuation of harmful stereotypes.
Ans De Nolf +3 more
doaj +1 more source
, 2004 The September issue of ScieCom.info is now online. The editor's introduction is in Swedish but all the articles are in English. (Thanks to Ingegerd Rabow.) Ulla Carlson, Open Access and Journal Publication in the Social Sciences and the Humanities Marcus Uneson, Tomorrow´s File Endings: On Archiving Principles and Archiving Formats Inge-Bert ...
openaire +1 more source
, 1981 This item contains two issues of the Take One newsletter: September 3, and 17, 1981Take One was published every two weeks and focused on short news items and announcements "for the people of University Hospital.
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source