Results 121 to 130 of about 858,737 (291)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Potraits of Women in Republika Online News: a Corpus Linguistic Analysis

open access: yesSuar Betang
The news media's depiction of women tends to produce various perceptions that are negative, positive, or neutral. That statement is displayed based on language and word sorting in expressing each event.
Al Lastu Nurul Fatim   +3 more
doaj   +1 more source

Analisis Isi Berita Pembangunan Periklanan Dan Kelautan Pada Surat Kabar Kaltim Post [PDF]

open access: yes, 2008
The objectives of this research were to explain the characteristic of the newspaper’s profile of fishery and marine development, to compare the objectiveity of the reports based on the result of censuses of fishery and marine science and mass media ...
Sugiharto, E. (Eko)
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Kaepernick’s Kneel: A Misinterpretation of a Movement [PDF]

open access: yes, 2018
Overview: I am most proud of singing the national anthem. It gave me the opportunity to share my musical gift, building my confidence along the way. I performed the national anthem for over thirty athletic events. I sang for a men’s regional hockey game,
Costello, Meghan
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Learning in both worlds : academic journalism as a research outcome [PDF]

open access: yes, 2012
Works of journalism by journalism academics can be valuable outcomes of research without making the claim that they are scholarly works per se. In the discussion of the feature article Learning in both worlds that follows, I make a case for the ...
Waller, Lisa J.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

The Power and Pedagogy of Quotations : Using a Political News Story in an EFL Classroom [PDF]

open access: yes, 2011
小論では外国語として英語を学ぶ学生が、政治的なニュース記事におけるメディア・アクセス‘media access\u27 を評価する方法について調査した。まず始めに、メディアの重点やメディア・アクセスのポイントとして、引用箇所がどのような役割を果たしているのかについて論じた。その後、学生に実際のニュース記事を読ませる活動についての考察を行った。授業では、学生はニュース記事を取り上げるプランを作成し、それをもとに、同じテーマを扱った実際のニュース記事を評価する ...
DEUSEN Brendan VAN, VAN DEUSEN Brendan
core   +1 more source

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