Results 71 to 80 of about 866,689 (290)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Phenomenon of Artificial Intelligence Usage in News Writing Styles by Journalists of Bengkulu Ekspress.com

Komunikator
The emergence of Artificial Intelligence (AI) technology in journalism has brought about significant changes. Equipped with AI-powered tools, this technology has become an integral part of journalistic work, transforming the way news is processed.
Indah Kurnianti, Dhanurseto Hadiprashada, Nurlianti Muzni, Sait Ceesay   +3 more
doaj   +1 more source

A Posthuman Cosmopolitanism and New Media Writing

Hyperrhiz: New Media Cultures, 2012
New media writing is often conceptualised in terms of the relationship between human and computers, a process Katherine Hayles calls intermediation (Hayles 2008). However critical writing on new media writing has not necessarily made a strong link between intermediation and interculturality.
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

MÉDIA PHOTOSTORY PIKEUN NGARONJATKEUN KAMAMPUH SISWA DINA NULIS WARTA: (Studi Kuasi Éskpérimén ka Siswa Kelas IX C SMP Kartika XIX-2 Bandung Taun Ajaran 2015/2016) [PDF]

, 2016
Kasang tukang ieu panalungtikan nya éta kurangna kamampuh nulis warta siswa kelas IX C SMP Kartika XIX-2 Bandung. Panalungtikan ieu miboga tujuan pikeun ngadéskripsikeun kamampuh nulis warta saméméh jeung sabada ngagunakeun média photostory jeung béda ...
Herdyani, Vemy Silvia
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Global connectivity through news: aspiration or fantasy? [PDF]

, 2010
Here are some draft notes for a paper I am writing on how people in the UK use the news media in an age of globalised communication. It’s taken out of context from the rest of the paper, but if it sparks any thoughts, or if you have any comments or ideas
Beckett, Charlie
core  

‘soundAFFECTs’: translation, writing, new media, affect

, 2009
This chapter will focus on the translation or trans-coding of a work from its print form as ‘AFFECTions: friendship, community, bodies’ (Brewster and Smith 2003) into its multimedia form as ‘soundAFFECTs’ (Dean et al. 2004). In particular, it will explore how this transition changes the affective experience the piece transmits.
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source