Results 91 to 100 of about 1,558,961 (274)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

News Value Dynamics – Communication Through Audience Experience Research

open access: yesПроблеми на постмодерността
News is a viable and essential form of traditional journalism. News television programming incorporates the seriousness of democratic issues into the public conversation.
Maya Vassileva
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Le retraitement automatisé de l’information d’actualité en ligne : analyse des mécanismes socio-techniques mis en place par les infomédiaires

open access: yesCommunication, 2012
The news infomediaries (news portals and news aggregators) play an increasingly central role in journalism. This research brief addresses the issue of the new meta-editorial function assumed by this emerging category of actors who do not invest in the ...
Marc-Olivier Goyette-Côté
doaj   +1 more source

The effective participation of the audience in the production of news: encouraging opportunities through data journalism [PDF]

open access: yes, 2018
Digital tools allow and encourage users "to participate in the creation and circulation of media” (Lewis, 2012). This participation can be considered as a remedy against the growing disconnection between journalism and citizens, also as a formula for a ...
Blanco-Castilla, Elena Pilar   +1 more
core  

P11 Resonances with Dubna-Mainz-Taipei Dynamical Model for pi-N Scattering and Pion Electromagnetic Production

open access: yes, 2011
We present the results on P11 resonances obtained with Dubna-Mainz-Taipei (DMT) dynamical model for pion-nucleon scattering and pion electromagnetic production. The extracted values agree well, in general, with PDG values. One pole is found corresponding
Kamalov, S. S.   +2 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Gatewatching Behind the Beating Case of Ratna Sarumpaet in Tribunnews.com and Detik.com

open access: yesKomunikator, 2019
The existence of social media fosters a public role in the production of news in online media. Through social media, the public acts as a curator of crucial issues and news sources. This study uses Axel Bruns'sgatewatching theory that emphasizes the role
Sundari Sundari, Ummi Salamah
doaj   +1 more source

Kamasutra1 Journalism; Degradation of News Quality in Online Media in Indonesia [PDF]

open access: yes, 2010
Online media in Indonesia is called secondary journalism as it gives priority on speed and tends to ignore other journalism principles such as accuracy and completeness.
Nurul, Hasfi
core  

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