Results 81 to 90 of about 1,062,070 (237)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
ONLINE MEDIA AND JOURNALISM ON SOCIAL NETWORKS – CASE STUDY SOCIAL NETWORK FACEBOOK [PDF]
Hum, 2019 Media and journalism have survived revolutionary changes through development of internet and information and communications technologies while the multimedia character of news processing has changed forms of collecting, production, editing and publishing
Siniša Kovačić +2 more
doaj
City Magazine Editors and the Evolving Urban Information Environment [PDF]
, 2014 The urban information environment in which city magazines operate is changing dramatically, with the decline of local newspapers and the growth of user-generated local content.
Sivek, Susan Currie
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Predatory Publishing - Herausforderung für Wissenschaftler/innen und Bibliotheken
o-bib. Das offene Bibliotheksjournal, 2019 Predatory Publishing ist seit der umfangreichen internationalen Medienberichterstattung im Sommer 2018 auch der breiten Öffentlichkeit ein Begriff.
Clara Ginther, Karin Lackner
doaj +1 more source
Proposta de uma aplicação Web para monitorização do impacto de notícias nas redes sociais Facebook e Twitter [PDF]
, 2013 Este artigo resume os principais resultados de uma investigação que teve por objetivo a conceção, prototipagem e validação de uma aplicação web destinada a monitorizar o impacto de um conteúdo publicado nas redes sociais (Facebook e Twitter).
Caixinha, Helder +2 more
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source