The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
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Trust in Media, Trust in Science, Political Party, Big Five Personality Traits, and Vaccination Intention: A Cross-Sectional Study. [PDF]
Johnson EK, Meadows C, Zhang Meadows CC.
europepmc +1 more source
The predictive value of the National Early Warning Score for mortality and independent prognostic factors in patients with coronavirus disease 2019: A retrospective cohort study. [PDF]
Zhang X, Li F.
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Down Syndrome in British Maternity Care: Mothers' Experiences of Prenatal Testing and Receiving a Prenatal or Postnatal Diagnosis. [PDF]
Rutter T +5 more
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Impact of YouTube User-Generated Content on News Dissemination and Youth Information Reception. [PDF]
Chunqiong W +3 more
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Editorial: The multiple applications of marine-derived bioactives. [PDF]
Rijo P, Tasdemir D, Rotter A.
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Rethinking news framing with large language models. [PDF]
Tohidi A, Haider S, Watts DJ.
europepmc +1 more source
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JAMA: The Journal of the American Medical Association, 1968The following is the first report on a new computer, called Hyperbroca, which is capable of translating one English style into another. This unit will affect all writing, in science as well as in fiction. I shall present a brief history of the computer's development, a sample of what the machine can do, and a preview of the changes it might bring and ...
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