Results 211 to 220 of about 519,004 (292)

Monitoring Variant Allele Fraction in VEXAS Syndrome: A Comparison of Digital PCR and Next-Generation Sequencing. [PDF]

EJHaem
Exposito-Bey A, Montes-Cano MA, Payán-Pernía S, García-Lozano JR, González-Escribano MF.   +4 more
europepmc   +1 more source

De Novo Assembly of Human Herpes Virus Type 1 (HHV-1) Genome, Mining of Non-Canonical Structures and Detection of Novel Drug-Resistance Mutations Using Short- and Long-Read Next Generation Sequencing Technologies

, 2016
Timokratis Karamitros, Ian Harrison, Renata Piorkowska, Aris Katzourakis, Gkikas Magiorkinis, Jean L. Mbisa   +5 more
openalex   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Identification of novel germline and somatic mutations associated with hepatocellular carcinoma by next-generation sequencing. [PDF]

Front Pharmacol
Laaribi AB, Babay W, Lekired A, Bouchabou B, Mehri A, Bacha D, Sassi R, Ben Slama S, Bayar R, Omrani S, Boujelbene N, Ennaifer R, Arfa N, Lahmar A, Ouzari HI.   +14 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Exploring the microbial diversity of the distal intestinal lumen and mucosa of farmed rainbow troutOncorhynchus mykiss(Walbaum) using next generation sequencing (NGS)

, 2015
Philip Lyons, James Turnbull, K. A. Dawson, Margaret Crumlish   +3 more
openalex   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Clinical actionability in gliomas revealed by real-world next-generation sequencing: a multicentric study. [PDF]

NPJ Precis Oncol
Mirallas O, Ruiz-Pace F, Velilla G, Gómez-Puerto D, Gorria T, Yaringaño J, Martínez-Monino Á, López-Valbuena D, Vaz MA, Hernandez A, Martínez-Saez E, Sorolla MA, Castro-Henriques M, Bardaji JL, Di Muzio A, Gallego O, Martínez-García M, Domenech M, Carles J, Balaña C, Pineda E, Dienstmann R, Sepúlveda JM, Vieito M.   +23 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

In vivo tracking of transfused platelets by next-generation sequencing of mitochondrial DNA. [PDF]

Blood Adv
Choi SJ, Kwon SS, Kim HK, Suh EJ, Chung H, Cho H, Cheong JW, Kim S.   +7 more
europepmc   +1 more source