Results 311 to 320 of about 1,460,723 (393)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Targeted next-generation sequencing characterization of respiratory pathogens in children with acute respiratory infection. [PDF]

BMC Infect Dis
Li C, Zhang X, Liu P, Lu M, Xiao L, Ou F, Deng H, Zhang W, Deng Z, Luo S.   +9 more
europepmc   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

The Novel HLA-E*01:152 Allele Identified in African Populations Using Next-Generation Sequencing. [PDF]

HLA
Naidoo N, Ng'uni TL, Padia U, Banjoko AW, Ndhlovu ZM.   +4 more
europepmc   +1 more source

Rapid development of microsatellite markers for Culicoides obsoletus using next generation sequencing [PDF]

, 2015
Argout, Xavier, Balenghien, Thomas, Gardes, Laëtitia, Garros, Claire, Huber, Karine, Rivallan, Ronan, Vignes, Hélène   +6 more
core  

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations

Nature reviews genetics, 2018
J. Salk, Michael W. Schmitt, L. Loeb
semanticscholar   +1 more source

Metagenomic next-generation sequencing of alveolar lavage fluid improves the detection of pulmonary infection. [PDF]

Open Life Sci
Meng Z, Li D, Yang W, Tang J.
europepmc   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Cryosurgery and Next-Generation Sequencing Unravel Talaromycosis Mimicking an Airway Tumor: A Case Report. [PDF]

Infect Drug Resist
Zhang Q, Zheng F, Pang Z, Xiang Y, Wang S.   +4 more
europepmc   +1 more source