Results 321 to 330 of about 1,460,723 (393)

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Next Generation Sequencing Provides Rapid Access to the Genome of Puccinia striiformis f. sp. tritici, the Causal Agent of Wheat Stripe Rust

, 2011
Dario Cantù, Manjula Govindarajulu, Alex Kozik, Meinan Wang, Xianming Chen, Kenji K. Kojima, Jerzy Jurka, Richard W. Michelmore, Jorge Dubcovsky   +8 more
openalex   +2 more sources

Comprehensive analysis of culture-negative periprosthetic joint infection with metagenomic next-generation sequencing. [PDF]

Front Cell Infect Microbiol
Lin L, Li J, Zhang C, Li J, Wu B, Huang Z, Lv J, Liu M, Li W, Zhang W, Fang X.   +10 more
europepmc   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Diagnosis of Mycoplasma Hominis Peritonitis in a CAPD Patient with Metagenomic Next-Generation Sequencing: A Case Report. [PDF]

Infect Drug Resist
Deng C, Hong L, Sun D, Miao H, Tang F, Li Z, Liu X.   +6 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Next‑generation sequencing failure rates in rare tumors: A real‑world single‑institution analysis. [PDF]

Med Int (Lond)
Itkin B, Deshpande PA, Pullanhi A, Al-Sayegh H, Abbas D, Al Zadjali S, Al Haddabi I.   +6 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Prospective Genomic Characterization of the German Enterohemorrhagic Escherichia coli O104:H4 Outbreak by Rapid Next Generation Sequencing Technology

, 2011
Alexander Mellmann, Dag Harmsen, Craig Cummings, Emily B. Zentz, Shana R. Leopold, Alain Rico, Karola Prior, Rafael Szczepanowski, Yongmei Ji, Wenlan Zhang, Stephen F. McLaughlin, John Henkhaus, Benjamin Leopold, Martina Bielaszewska, Rita Prager, Pius Brzoska, Richard Moore, Simone M Guenther, Jonathan M. Rothberg, Helge Karch   +19 more
openalex   +2 more sources

Comparative analysis of metagenomic next-generation sequencing for pathogenic identification in clinical body fluid samples. [PDF]

BMC Microbiol
Sun N, Zhang J, Guo W, Cao J, Chen Y, Gao D, Xia X.   +6 more
europepmc   +1 more source