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Sudden Cardiac Death: The Role of Molecular Autopsy with Next-Generation Sequencing. [PDF]
Diagnostics (Basel)Fadoni J, Santos A, Amorim A, Cainé L.
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Sequencing technologies — the next generation [PDF]
Nature Reviews Genetics, 2010 Demand has never been greater for revolutionary technologies that deliver fast, inexpensive and accurate genome information. This challenge has catalysed the development of next-generation sequencing (NGS) technologies. The inexpensive production of large volumes of sequence data is the primary advantage over conventional methods.
M. Metzker
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Next-generation DNA sequencing
Nature Biotechnology, 2008DNA sequence represents a single format onto which a broad range of biological phenomena can be projected for high-throughput data collection. Over the past three years, massively parallel DNA sequencing platforms have become widely available, reducing the cost of DNA sequencing by over two orders of magnitude, and democratizing the field by putting ...
J. Shendure, Hanlee P. Ji
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2016
Endometrial cancers are the most frequently diagnosed gynecological malignancy and were expected to be the seventh leading cause of cancer death among American women in 2015. The majority of endometrial cancers are of serous or endometrioid histology. Most human tumors, including endometrial tumors, are driven by the acquisition of pathogenic mutations
Daphne W. Bell +2 more
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Endometrial cancers are the most frequently diagnosed gynecological malignancy and were expected to be the seventh leading cause of cancer death among American women in 2015. The majority of endometrial cancers are of serous or endometrioid histology. Most human tumors, including endometrial tumors, are driven by the acquisition of pathogenic mutations
Daphne W. Bell +2 more
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Benchmarking variant callers in next-generation and third-generation sequencing analysis
Briefings Bioinform., 2020DNA variants represent an important source of genetic variations among individuals. Next- generation sequencing (NGS) is the most popular technology for genome-wide variant calling. Third-generation sequencing (TGS) has also recently been used in genetic
Surui Pei +5 more
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Neuromuscular Disorders, 2019
Next-generation sequencing (NGS) is a powerful technology that allows for high-throughput multiplex sequencing. This chapter reviews the key steps in NGS wet lab and dry lab processing. The library preparation process prepares the substrates to be sequenced through nucleic acid isolation, fragmentation, isolation, end repair, adapter ligation, size ...
B. Udd +5 more
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Next-generation sequencing (NGS) is a powerful technology that allows for high-throughput multiplex sequencing. This chapter reviews the key steps in NGS wet lab and dry lab processing. The library preparation process prepares the substrates to be sequenced through nucleic acid isolation, fragmentation, isolation, end repair, adapter ligation, size ...
B. Udd +5 more
openaire +4 more sources
Next-generation sequencing in the clinic
Nature Biotechnology, 2013Pools of cell lines carrying a variety of known mutations are used to validate the performance of a cancer diagnostic test based on next-generation sequencing.
Jason Y. Park +2 more
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Next Generation Sequencing: Transcriptomics
2021Fungal transcriptomics is a rising field which has gained attention in the last two decades. The recent democratization of high throughput next-generation sequencing (NGS) techniques for large-scale transcriptomic analysis provided the opportunity to explore transcriptomes at an unprecedented level of resolution.
Sillo, Fabiano
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Next-Generation Sequencing in Cancer
Journal of Maxillofacial and Oral Surgery, 2020In this article, we provide a gestalt idea about NGS technologies and their applications in cancer research and molecular diagnosis.Next-generation sequencing (NGS) advancements like DNA sequencing and RNA sequencing allow uncovering of genomic, transcriptomic, and epigenomic scenes of individual malignant growths.
S. Vinod Nair +3 more
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J. Comput. Biol., 2017
Cutting of primers from reads is an important step of processing targeted amplicon-based next generation sequencing data. Existing tools are adapted for cutting of one or several primer/adapter sequences from reads and removing all of their occurrences ...
A. Kechin +3 more
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Cutting of primers from reads is an important step of processing targeted amplicon-based next generation sequencing data. Existing tools are adapted for cutting of one or several primer/adapter sequences from reads and removing all of their occurrences ...
A. Kechin +3 more
semanticscholar +1 more source