Results 111 to 120 of about 632,857 (301)
Energy transfers in dynamos with small magnetic Prandtl numbers
, 2015 We perform numerical simulation of dynamo with magnetic Prandtl number $\mathrm{Pm} =0.2$ on $1024^3$ grid, and compute the energy fluxes and the shell-to-shell energy transfers.
Kumar, Rohit +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Broadband : towards a national plan for Scotland [PDF]
, 2012 The development of national broadband plans has been used by many countries to join up different areas of governmental and regulatory activities and to set ambitious targets for ubiquitous access to and use of the latest fixed and wireless networks and ...
Lockyer, Cliff, Sutherland, Ewan
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Some Implications of GM Food Technology Policies for Sub-Saharan Africa [PDF]
The first generation of genetically modified (GM) crop varieties sought to increase farmer profitability through cost reductions or higher yields.
Kym Anderson, Lee Ann Jacskon
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Fiskalkompetenzen nach Next Generation EU: Juristische Ingenieurskunst? [PDF]
JuWissBlog
openaire +1 more source
Low-Carbon Technologies in the Post-Bali Period: Accelerating their Development and Deployment. CEPS ECP Report No. 4, 4 December 2007 [PDF]
, 2008 This report analyses the very broad issue of technology development, demonstration and diffusion with a view to identifying the key elements of a complementary global technology track in the post-2012 framework.
Egenhofer, Christian. +2 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source