Results 101 to 110 of about 5,172,921 (307)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2011 During recent years, several podocyte genes have been implicated in severe forms of steroid-resistant nephrotic syndrome (SRNS) progressing to renal failure.
P. Romagnani +9 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 2016 ‘Next generation sequencing’ technology in routine analysis in Belgian healthcare system.
M. Van den Bulcke
core
Maybe More Than Mates, Maybe Not? The Modern Meaning of a Modern Alliance
, 2022 Article in Next-generation perspectives on the US–Australia alliance (Next Generation Perspectives Policy Paper; August 2022)Benjamin Cherry-Smith, Renee Cremer, Monique Currie and Jena ...
Cremer, R. +3 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies
, 2019 The introduction and advances on next-generation sequencing have led to novel ways to integrate simultaneous assessment of multiple target genes in routine laboratory analysis.
Fulya Öz Puyan +3 more
core +1 more source
Frontiers in Genetics, 2019 Modification mapping from cDNA data has become a tremendously important approach in epitranscriptomics. So-called reverse transcription signatures in cDNA contain information on the position and nature of their causative RNA modifications. Data mining of,
Lukas Schmidt +14 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation [PDF]
, 2010 New sequencing technologies, such as Roche 454, ABI SOLiD and Illumina, have been increasingly developed at an astounding pace with the advantages of high throughput, reduced time and cost.
Teng, Huajing +8 more
core +3 more sources