Results 141 to 150 of about 5,172,921 (307)
Bioinformatics' approaches to detect genetic variation in whole genome sequencing data [PDF]
, 2010 Current genetic marker repositories are not sufficient or even are completely lacking for most farm animals. However, genetic markers are essential for the development of a research tool facilitating discovery of genetic factors that contribute to ...
Kerstens, H.H.D.
core
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
The Evolution of Next-Generation Sequencing Technologies
The genetic information that dictates the structure and function of all life forms is encoded in the DNA. In 1953, Watson and Crick first presented the double helical structure of a DNA molecule. Their findings unearthed the desire to elucidate the exact composition and sequence of DNA molecules.
Akintunde, Olaitan +2 more
openaire +4 more sources
Metagenomic Next-Generation Sequencing Reveals Porphyromonas gingivalis in Geriatric Severe Pneumonia Complicated by Empyema: Case Report [PDF]
Na Guo,1,* Guannan Ma,2,* Huimin Liu,1 Jingxuan Qiu,1 Yan Yu,1 Yunlei Gao,1 Zhong Yi,1 Zhirong Wan,1 Lei Zhang,2,3 Xiaorui Wu4 1Department of Geriatrics, Aerospace Center Hospital, Beijing, People’s Republic of China; 2Medical Research ...
Guo N +9 more
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
희귀 신경근 질환의 유전체, 전사체 통합 분석 연구 [PDF]
, 2019 학위논문(석사)--서울대학교 대학원 :의과대학 의과학과,2019. 8. 최무림.Whole exome sequencing (WES)은 비용 및 데이터 처리의 용이성으로 인하여 희귀질환 진단등에 매우 효과적인 방법이 되었다. 그러나 variant of unknown significances (VUS)를 해석하는 어려움과non-coding 변이형을 확인할 수 없다는 점 등의 이유로 WES 기반의 희귀질환 진단률은 대부분 50%를 넘지 못한다.
Jana Kneissl
core
Chromosome-level phased genome assembly of the argan tree Sideroxylon spinosum
Scientific DataArgan (Sideroxylon spinosum L., formerly Argania spinosa) is a tree endemic to Morocco, primarily valued for its seed oil. Growing interest in its biology and in genes linked to oil quality and stress resistance highlights the need for high-quality ...
Ivan D. Mateus +6 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Next‐generation sequencing for next‐generation breeding, and more [PDF]
New Phytologist, 2013 openaire +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source