Results 191 to 200 of about 978,334 (297)

Next Generation Sequencing of Tracheal Aspirates in Children With Tracheostomy A Prospective Case-Control Study. [PDF]

Pediatr Pulmonol
Brensing P, Lutynski J, Hilder M, Brenner T, Mazzitelli S, Grumaz S, Stehling F.   +6 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Molecular Characterization of Soft Tissue Sarcomas Using RNA-Based Next-Generation Sequencing. [PDF]

Int J Mol Sci
Serban B, Cursaru A, Iordache S, Cretu B, Nica M, Iacobescu G, Popa M, Radu E, Cirnu M, Cirstoiu C.   +9 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

The clinical value of metagenomic next generation sequencing in the diagnosis of non-neutropenic invasive pulmonary aspergillosis. [PDF]

Front Cell Infect Microbiol
Zhong H, Sun C, Lu Y, Cai X, Cao M, Wang L, Feng C, Song M, Sun W, Shi M, Tao Y, Zhou J, Chen C, Lu X, Li Y, Ni Y, Cai Y, Zhong J, Li Y, Wu W, Shi Y, Wang M, Su X.   +22 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Rapid development of microsatellite markers for Culicoides obsoletus using next generation sequencing [PDF]

, 2015
Argout, Xavier, Balenghien, Thomas, Gardes, Laëtitia, Garros, Claire, Huber, Karine, Rivallan, Ronan, Vignes, Hélène   +6 more
core  

Next generation sequencing in dilated cardiomyopathy: utility and challenges in the African context. [PDF]

Front Cardiovasc Med
Mayisela M, Mpanya D, Adamu UG, Mpangase PT, Lombard Z, Amoni J, Mboweni N, Tsabedze N.   +7 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Integrating Rapid Lymphoma Next-Generation Sequencing Panel-Based Testing into Routine Genomic Diagnostics. [PDF]

Ann Lab Med
Shin S, Lee ST.
europepmc   +1 more source