Results 41 to 50 of about 13,316 (185)

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism

Annals of Neurology, EarlyView.
Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono, Hiroaki Sekiya, Alexia R. Maier, Neill R. Graff‐Radford, Zbigniew K. Wszolek, Dennis W. Dickson   +5 more
wiley   +1 more source

From the Gutenberg Galaxy to the Metaverse: Third Generation Internet, Web 3.0

Online Academic Journal of Information Technology, 2022
Birinci kuşak internet olarak anılan Web 1.0’ın tek yönlü iletişim ortamı kısa sürede yerini Web 2.0’ın etkileşimli dairesel iletişimine bırakmıştır. Araştırmacıların birçoğu Web 2.0 üzerinde geliştirilen Semantik webin internetin yeni kuşağı olacağını ...
İbrahim Sena Arvas
doaj   +1 more source

Recent Insights Into Alzheimer's Disease: Advances in Pathophysiology and Therapeutic Strategies

Brain Health, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a complex neurodegenerative disorder driven by interplay among amyloid‐β (Aβ) plaques, tau neurofibrillary tangles, inflammation and comorbid pathologies. Recent advances in biomarkers and therapeutic approvals have reshaped our understanding of its pathophysiology and treatment landscape.
Jiong Shi, Jeffery Cummings, Jacques Touchon, Bruno Vellas   +3 more
wiley   +1 more source

Between sales mechanism and medium: Art in the age of blockchain and NFT

Acta Universitatis Wratislaviensis. Prace Kulturoznawcze
The text considers the status of NFT artwork and how it is affected by its close relationship with blockchain. Doubts about the media character of NFT art are raised.
Ryszard W. Kluszczyński
doaj   +1 more source

Consumer Responses to Physical, Digital and Integrative Sustainability Strategies in the Apparel Industry: A Systematic Review

Business Strategy and the Environment, EarlyView.
ABSTRACT The apparel industry is one of the world's most profitable sectors but also among the most environmentally damaging. Growing sustainability pressures have led companies to adopt diverse strategies to reduce their impact, yet no single study has systematically analysed these approaches or their consumer implications.
Maria Leonor Ferreira, João J. Ferreira   +1 more
wiley   +1 more source

On the Efficiency of Individualized Theta/Beta Ratio Neurofeedback Combined with Forehead EMG Training in ADHD Children

Frontiers in Human Neuroscience, 2018
Background: Neurofeedback training (NFT) to decrease the theta/beta ratio (TBR) has been used for treating hyperactivity and impulsivity in attention deficit hyperactivity disorder (ADHD); however, often with low efficiency.
Olga M. Bazanova, Olga M. Bazanova, Tibor Auer, Tibor Auer, Elena A. Sapina, Elena A. Sapina   +5 more
doaj   +1 more source

Unlocking Iron Redox Depth for High‐Energy Layered Sodium Oxide Cathodes

Carbon Energy, EarlyView.
Valence engineering strategy is introduced into layered NiFeMn‐based oxide cathodes to intensify the cationic redox capacity by reconfiguring Fe's local chemical environment and unlocking unprecedented redox depth. The cathode shows reversible O3 → P3 → OP2 transition, low volume variation, and high structural integrity.
Yadong Song, Wujie Dong, Zhuoran Lv, Bingyuan Han, Jiaming Li, Xin Wang, Xinxin Wang, Jingjing Chen, Chenlong Dong, Zhiyong Mao, Lianqi Zhang   +10 more
wiley   +1 more source

Effects of Promotional Bundles with Non-Fungible Token (NFT) Fashion on Consumers’ Perceptions

Journal of Theoretical and Applied Electronic Commerce Research
The rapid expansion of the non-fungible token (NFT) market, which grew over 200% in 2023 to reach $22 billion, has opened new avenues for fashion brands to engage consumers through digital fashion products under blockchain technology.
Seong Eun Kim, Jung Eun Lee, Song-yi Youn   +2 more
doaj   +1 more source