Results 91 to 100 of about 11,425 (225)

Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease [PDF]

Journal of Negative Results in BioMedicine, 2012
Loss of basal forebrain cholinergic neurons is attributable to the proapoptotic signaling induced by nerve growth factor receptor (NGFR) and may link to Alzheimer's disease (AD) risk. Only one study has investigated the association between NGFR polymorphisms and the risk of AD in an Italian population.
Cheng, Hui-Chi, Sun, Yu, Lai, Liang-Chuan, Chen, Shih-Yuan, Lee, Wen-Chung, Chen, Jen-Hau, Chen, Ta-Fu, Chen, Hua-Hsiang, Wen, Li-Li, Yip, Ping-Keung, Chu, Yi-Min, Chen, Wei J, Chen, Yen-Ching   +12 more
openaire   +2 more sources

Heterogeneity‐induced NGF‐NGFR communication inefficiency promotes mitotic spindle disorganization in exhausted T cells through PREX1 suppression to impair the anti‐tumor immunotherapy with PD‐1 mAb in hepatocellular carcinoma

Cancer Medicine
Background The mechanism of decreased T cells infiltrating tumor tissues in hepatocellular carcinoma is poorly understood. Methods Cells were separated from the single‐cell RNA‐sequence dataset of hepatocellular carcinoma patients (GSE149614) for cell ...
Xin Wang, Tongwang Yang, Shangheng Shi, Chuanshen Xu, Feng Wang, Deshu Dai, Ge Guan, Yong Zhang, Shuxian Wang, Jianhong Wang, Bingliang Zhang, Peng Liu, Xiaoshuai Bai, Yan Jin, Xinqiang Li, Cunle Zhu, Dexi Chen, Qingguo Xu, Yuan Guo   +18 more
doaj   +1 more source

Dysregulation of NAD+ metabolism induces a Schwann cell dedifferentiation program [PDF]

, 2018
The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the
Hackett, Amber R, Kim, Sungsu, Milbrandt, Jeffrey, Sasaki, Yo, Strickland, Amy   +4 more
core   +1 more source

Bridging Mechanistic and Phenomenological Models of Complex Biological Systems

, 2016
The inherent complexity of biological systems gives rise to complicated mechanistic models with a large number of parameters. On the other hand, the collective behavior of these systems can often be characterized by a relatively small number of ...
Qiu, Peng, Transtrum, Mark K.
core   +2 more sources

Expressão de HLA-DR em nervo periférico de esclerose lateral amiotrófica [PDF]

, 1994
To investigate the possibility of local antigen presentation within the peripheral nerve in amyotrophic lateral sclerosis (ALS), cryostat sections of 83 peripheral nerve biopsies were stained for the demonstration of HLA-DR using a monoclonal antibody ...
Gabbai, Alberto Alain, Hays, A.p., Isozaki, E., Oliveira, Acary Souza Bulle, Younger, D.   +4 more
core   +1 more source

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

British Journal of Pharmacology, Volume 183, Issue 5, Page 1122-1139, March 2026.
Abstract Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood.
Elisa Kiselev, Wilson Agyapong, Bjarne Jürgens, Elisa Mohr, Shambhabi Chatterjee, Hannah J. Hunkler, Jawad Salman, Giuseppe Cipriano, Marco Bentele, Junqing Liu, Jonas Specht, Kaja S. Menge, Florian J. G. Waleczek, Jonas A. Haas, Anselm A. Derda, Kristina Sonnenschein, Anika Gietz, Susanne Neumüller, Angelika Pfanne, Oliver Beetz, Michael Pflaum, Bettina Wiegmann, Yiangos Psaras, Christopher Toepfer, Robert Zweigerdt, Ante Radocaj, Theresia Kraft, Andre Zeug, Evgeni Ponimaskin, Wilhelm Korte, Alexander Horke, Arjang Ruhparwar, Maximilian Fuchs, Ke Xiao, Christian Bär, Natalie Weber, Thomas Thum   +36 more
wiley   +1 more source

Identification and mechanistic analysis of neurovascular coupling related biomarkers for diabetic macular edema

Frontiers in Molecular Biosciences
IntroductionDiabetic macular edema (DME) is a major cause of vision loss in the sick with diabetic retinopathy. The occurrence of DME is closely related to the breakdown of neurovascular coupling; however, its underlying mechanism has not been fully ...
Tianpeng Chen, Tianpeng Chen, Tianpeng Chen, Tianpeng Chen, Shufan Sheng, Shufan Sheng, Shufan Sheng, Shufan Sheng, Shufan Sheng, Jing Chen, Jing Chen, Jing Chen, Jing Chen, Jing Chen, Xiaole Wang, Xiaole Wang, Xiaole Wang, Xiaole Wang, Xiaole Wang, Yanxing Shang, Yanxing Shang, Yanxing Shang, Yanxing Shang, Chengwei Duan, Chengwei Duan, Chengwei Duan, Chengwei Duan, Caixia Liang, Caixia Liang, Caixia Liang, Caixia Liang, Yu Song, Yu Song, Yu Song, Yu Song, Yu Song, Dongmei Zhang, Dongmei Zhang, Dongmei Zhang, Dongmei Zhang   +39 more
doaj   +1 more source

An immunohistochemical, clinical and electroneuromyographic correlative study of the neural markers in the neuritic form of leprosy

Brazilian Journal of Medical and Biological Research, 2006
The nerve biopsies of 11 patients with pure neuritic leprosy were submitted to routine diagnostic procedures and immunoperoxidase staining with antibodies against axonal (neurofilament, nerve growth factor receptor (NGFr), and protein gene product (PGP ...
S.L.G. Antunes, L.M. Chimelli, E.T. Rabello, V.C. Valentim, S. Corte-Real, E.N. Sarno, M.R. Jardim   +6 more
doaj   +1 more source

circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation

eLife, 2020
Circular RNAs are important for many cellular processes but their mechanisms of action remain poorly understood. Here, we map circRNA inventories of mouse embryonic stem cells, neuronal progenitor cells and differentiated neurons and identify hundreds of
Anne Kruse Hollensen, Henriette Sylvain Thomsen, Marta Lloret-Llinares, Andreas Bjerregaard Kamstrup, Jacob Malte Jensen, Majbritt Luckmann, Nanna Birkmose, Johan Palmfeldt, Torben Heick Jensen, Thomas B Hansen, Christian Kroun Damgaard   +10 more
doaj   +1 more source

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source