Results 101 to 110 of about 11,425 (225)

Overexpression of hsa-miR-939 follows by NGFR down-regulation and apoptosis reduction

Journal of Biosciences, 2017
Neurotrophin receptors play a crucial role in neuronal survival, differentiation and regeneration. Nerve growth factor receptor (NGFR) or P75NTR is a neurotrophin receptor that is involved in many pathological conditions including cancers. Genetic factors that are involved in regulation of neurotrophin receptors are under intense investigation.
Fahimeh Hosseini, Aghdaei, Bahram M, Soltani, Sadat, Dokanehiifard, Seyed Javad, Mowla, Masoud, Soleimani   +4 more
openaire   +2 more sources

Nerve growth factor receptor limits inflammation to promote remodeling and repair of osteoarthritic joints

Nature Communications
Osteoarthritis (OA) is a painful, incurable disease affecting over 500 million people. Recent clinical trials of the nerve growth factor (NGF) inhibitors in OA patients have suggested adverse effects of NGF inhibition on joint structure.
Lan Zhao, Yumei Lai, Hongli Jiao, Jian Huang   +3 more
doaj   +1 more source

NGF-NGFR communication inefficiency induces T Cell exhaustion impairing PD-1 immunotherapy in hepatocellular carcinoma [PDF]

, 2023
Tongwang Yang, Qingguo Xu, Chuanshen Xu, Feng Wang, Deshu Dai, Ge Guan, Yong Zhang, Shuxian Wang, Jianhong Wang, Xiaoshuai Bai, Yan Jin, Shangheng Shi, Xinqiang Li, Cunle Zhu, Dexi Chen, Xin Wang, Yuan Guo   +16 more
openalex   +1 more source

The role of p75NTR in cholinergic basal forebrain structure and function [PDF]

, 2014
The role of the p75 neurotrophin receptor (p75NTR) in adult cholinergic basal forebrain (cBF) neurons is unclear due to conflicting results from previous studies and to limitations of existing p75NTR-knock-out mouse models. In the present study we used a
Alfonsi, Fabienne, Boskovic, Zoran, Coulson, Elizabeth J., Fonseka, Sachini, Rumballe, Bree A., Windels, Francois   +5 more
core   +1 more source

Engineering Ultrasound Contrast Agents for Targeted Therapeutics: A Theranostic Approach to Drug Delivery, Gene Therapy, and Immunomodulation

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza, Kimia Mozahheb Yousefi, Sara Minaeian   +2 more
wiley   +1 more source

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance [PDF]

, 2017
Continuous BRAF inhibition of BRAF mutant melanomas triggers a series of cell state changes that lead to therapy resistance and escape from immune control before establishing acquired resistance genetically. We used genome-wide transcriptomics and single-
Comin-Anduix, Begonya, Garcia-Diaz, Angel, Graeber, Thomas G., Heath, James R., Homet Moreno, Blanca, Kim, Jungwoo, Koya, Richard C., Lee, Jihoon W., Ng, Rachel H., Ribas, Antoni, Robert, Lidia, Su, Yapeng, Tsoi, Jennifer, Wei, Wei, Xue, Min   +14 more
core   +2 more sources

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells [PDF]

, 2017
Several lines of evidence have suggested that stemness and acquired resistance to targeted inhibitors or chemotherapeutics are mechanistically linked. Here we observed high cell surface and total levels of nerve growth factor receptor/CD271, a marker of ...
Khouja, S., Klinger, B., Redmer, T., Regenbrecht, C., Schaefer, R., Walz, I., Welte, Y.   +6 more
core   +1 more source

A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts

European Journal of Immunology, Volume 56, Issue 1, January 2026.
Picture‐book compartmentalization makes tonsillar tissue an ideal model to study spatial immunology. Using single‐molecule imaging (SMI) of whole‐tissue sections, we showcase many an alternative view on tissue composition and architecture that these data and concomitant analyses provide—at the level of single cells, cellular neighborhoods, and ...
Helena L. Crowell, Laura Llaó‐Cid, Gerard Frigola, Samuel Gunz, Irene Ruano, Patricia Lorden, Max Ruiz, Marta Kulis, José Ignacio Martin‐Subero, Holger Heyn, Elias Campo, Anna Pascual‐Reguant   +11 more
wiley   +1 more source

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]

, 2016
Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R., Glass, S., He, Y.J., Hoskins, J.M., McLeod, H.L., Motsinger-Reif, A., Paul, J., Winham, S.J.   +7 more
core   +1 more source