Results 111 to 120 of about 11,425 (225)

Synergistic Strategies in Systemic Therapy for Advanced Hepatocellular Carcinoma

Global Challenges, Volume 10, Issue 1, January 2026.
This article comprehensively examines the evolving landscape of systemic therapy for advanced hepatocellular carcinoma. It covers the progress in tyrosine kinase inhibitors and immune checkpoint inhibitors, analyzes the efficacy of novel combination strategies, and discusses current challenges like drug resistance and the lack of biomarkers.
Yongxin Yu, Yulang Jiang, Yipeng Yang, Christian Glandorff, Wenzheng Fang, Mingyu Sun   +5 more
wiley   +1 more source

ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma

Oncotarget, 2016
Oral squamous cell carcinoma (OSCC) is a highly invasive and metastatic malignancy. The nerve growth factor receptor (NGFR) has been observed to be expressed on a subset of cells in OSCC, and NGFR+ cells have greater tumor-initiating capacity in vivo.
Chen, Chen, Shin, June Ho, Eggold, Joshua T., Chung, Man Ki, Zhang, Luhua H., Lee, Jeremy, Sunwoo, John B.   +6 more
openaire   +3 more sources

Next Generation Computing and Communication Hub for First Responders in Smart Cities

Sensors
This paper contributes to the development of a Next Generation First Responder (NGFR) communication platform with the key goal of embedding it into a smart city technology infrastructure.
Olha Shaposhnyk, Kenneth Lai, Gregor Wolbring, Vlad Shmerko, Svetlana Yanushkevich   +4 more
doaj   +1 more source

Stimulatory effect of gonadal hormones on fetal rat hippocampal neural proliferation requires neurotrophin receptor activation in vitro [PDF]

, 1999
To determine the effects of gonadal hormones on proliferation of the hippocampal neural cells, which are of importance in learning and memory function. 17β-Estradiol or testosterone was added to the culture at various concentrations.
Pan, Meixia, Zhang, Caixia
core   +1 more source

hiPSC‐Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial‐Like Cells

Glia, Volume 74, Issue 1, January 2026.
SCZ astrocytes display an increased pro‐inflammatory profile upon TNF‐α stimulation. Reactive SCZ astrocytes induce microglial‐like cells to assume a dystrophic phenotype. Reactive SCZ astrocytes limit iMGs' synaptoneurosome uptake and migration. ABSTRACT Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ)
Pablo L. Cardozo, Chia‐Yi Lee, Juliana P. S. Lacerda, Júlia S. Fahel, Pablo Trindade, Gabriela Vitória, Leonardo Chicaybam, Rafaela C. Cordeiro, Isaque J. S. de Faria, Nathália C. Silva, Yaovi M. H. Todjro, Joana C. do P. Maciel, Martin H. Bonamino, Luciene B. Vieira, Breno F. Cruz, Rodrigo Nicolato, Kristen J. Brennand, Stevens K. Rehen, Fabíola M. Ribeiro   +18 more
wiley   +1 more source

Modules identification in gene positive networks of hepatocellular carcinoma using pearson agglomerative method and Pearson cohesion coupling modularity [PDF]

, 2012
In this study, a gene positive network is proposed based on a weighted undirected graph, where the weight represents the positive correlation of the genes.
Gao, Zhiwei, Hu, Jinyu
core   +3 more sources

Lipid Droplet‐Driven Ribosome Collisions Trigger ZAKα‐p38 Signaling to Accelerate Testicular Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Aging‐ and obesity‐driven lipid droplet accumulation in Sertoli cells induces ROS‐mediated ribosome collisions, activating the ZAKα‐p38 pathway to accelerate testicular aging. Pharmacological ZAKα inhibition with Nilotinib rescues age‐related testicular dysfunction, identifying ribotoxic stress as a therapeutic target.
Yanghua Xu, Xiaoyan Shi, Yinghao Yin, Xiaoli Tan, Ningjing Ou, Xiaopeng Tang, Biao Liu, Hongshan Xie, Yuzhuo Chen, Zhitao Han, Jiarong Xu, Zitaiyu Li, Xiaoping Zheng, Hongji Hu, Wenjing Wang, Wanyi Xia, Hao Chen, Yuxin Tang, Liangyu Zhao   +18 more
wiley   +1 more source

Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats [PDF]

, 2016
Ovarian hormones regulate the transcriptome of the hippocampus and modulate its functions. During 29 menopause, this complex signaling declines, leading to impaired learning and memory.
Hrabovszky, Erik, Kalló, Imre, Liposits, Zsolt, Solymosi, Norbert, Sárvári, Miklós   +4 more
core   +1 more source

Impact of proNGF/NGF-NGFR-axis on the regulation of arterial remodelling [PDF]

European Heart Journal
Abstract Background Peripheral blood mononuclear cells (MNCs) contribute to the pathogenesis of arteriosclerosis. Nerve growth factor receptor (NGFR) is present in peripheral blood and the ischemic coronary artery.
S Takashima, S Usui, Chiaki Goten, Oto Inoue, Yoshihiro Takeda, Ken Yamaguchi, D Hashimuko, Masahiko Sugita, Yasuyuki Sakai, Ken‐ichiro Sakata, Masashi Takamura   +10 more
openalex   +2 more sources

Assessment of Melanoma-Initiating Cell Markers and Conventional Parameters in Sentinel Lymph Nodes of Malignant Melanoma [PDF]

, 2015
Sentinel lymph node (SLN) biopsies have widely been used for the detection of occult LN metastasis of malignant melanoma (MM). In addition to conventional biomarkers, we assessed the diagnostic and prognostic significance of melanoma-initiating cell (MIC)
Asagoe, Kenji, Hatta, Naohito, Iwatsuki, Keiji, Otsuka, Masaki, Shirafuji, Yoshinori, Suzuki, Norihiro, Takata, Minoru, Yamasaki, Osamu   +7 more
core   +1 more source