JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma. [PDF]
, 2016 A prominent mechanism of acquired resistance to BRAF inhibitors in BRAF (V600) -mutant melanoma is associated with the upregulation of receptor tyrosine kinases.
Atefi, Mohammad +16 more
core +3 more sources
Src kinase and Syk activation initiate PI3K signaling by a chimeric latent membrane protein 1 in Epstein-Barr virus (EBV)+ B cell lymphomas. [PDF]
PLoS ONE, 2012 The B lymphotrophic γ-herpesvirus EBV is associated with a variety of lymphoid- and epithelial-derived malignancies, including B cell lymphomas in immunocompromised and immunosuppressed individuals. The primary oncogene of EBV, latent membrane protein 1 (
Olivia Hatton +3 more
doaj +1 more source
Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression [PDF]
, 2015 Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has been reported in B-cells during the viral lytic ...
Alison J. Sinclair +77 more
core +1 more source
The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease
International Journal of Molecular Sciences, 2023 Alzheimer’s disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (Aβ) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space (amyloid plaques) and intracellular deposits of the hyperphosphorylated form of the protein tau (p-tau; tangles ...
Francesco Bruno +5 more
openaire +2 more sources
Animals, 2020 The grey squirrel is an invasive alien species that seriously threatens the conservation of the native red squirrel species. With the aim of characterizing the reproductive physiology of this species due to its great reproductive success, the function of
Margherita Maranesi +9 more
doaj +1 more source
Chronic nerve growth factor exposure increases apoptosis in a model of in vitro induced conjunctival myofibroblasts. [PDF]
PLoS ONE, 2012 In the conjunctiva, repeated or prolonged exposure to injury leads to tissue remodeling and fibrosis associated with dryness, lost of corneal transparency and defect of ocular function.
Alessandra Micera +4 more
doaj +1 more source
Cell Death Discovery, 2023 Levodopa-induced dyskinesia (LID) is a common motor complication in Parkinson’s disease. However, few studies have focused on the pathogenesis of LID at the transcriptional level. NONRATT023402.2, a long non-coding RNA (lncRNA) that may be related to LID
Qiao Wang +12 more
doaj +1 more source
Cartilage stem/progenitor cells are activated in osteoarthritis via interleukin-1β/nerve growth factor signaling [PDF]
, 2015 Introduction: Interleukin-1β (IL-1β) and nerve growth factor (NGF) are key regulators in the pathogenesis of inflammatory arthritis; specifically, IL-1β is involved in tissue degeneration and NGF is involved in joint pain.
Hu, C +6 more
core +3 more sources
Efficient Muscle Regeneration by Human PSC-Derived CD82+ ERBB3+ NGFR+ Skeletal Myogenic Progenitors
Cells, 2023 Differentiation of pluripotent stem cells (PSCs) is a promising approach to obtaining large quantities of skeletal myogenic progenitors for disease modeling and cell-based therapy. However, generating skeletal myogenic cells with high regenerative potential is still challenging.
Ning Xie +3 more
openaire +3 more sources
Pulmonary Circulation, 2021 Pulmonary arterial hypertension (PAH) remains a disease with a poor prognosis, so early detection and treatment are very important. Sensitive and non-invasive markers for PAH are urgently required.
Chiaki Goten +9 more
doaj +1 more source