Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity [PDF]
, 2015 The nuclear factor κB (NF-κB) pathway is a master regulator of inflammatory processes and is implicated in insulin resistance and pancreatic β cell dysfunction in the metabolic syndrome.
Brink, Robert +12 more
core +4 more sources
LMO1 Plays an Oncogenic Role in Human Glioma Associated With NF-kB Pathway
Frontiers in Oncology, 2022 BackgroundLIM domain only protein1(LMO1), a nuclear transcription coregulator, is implicated in the pathogenesis of T-cell acute lymphoblastic leukemia and neuroblastoma. However, the clinical significance and potential mechanism of LMO1 in human gliomas
Lei Gao +16 more
doaj +1 more source
Chronic alcohol abuse is implicated in the oxidative stress and the changes in the neurotrophic factor receptor expression in the human CNS [PDF]
, 2011 Alcohol abuse and alcoholism induce brain damage, and, in some cases, neurodegeneration. The pathogenesis of the alcohol-induced injury of the CNS is a complex process in which oxidative stress plays an essential role.
Groma, V., Kleina, R., Skuja, Sandra
core +3 more sources
Antibodies, 2023 Efficient induction of target-specific antibodies can be elicited upon immunization with highly immunogenic virus-like particles (VLPs) decorated with desired membrane-anchored target antigens (Ags).
Stefanie Schatz +6 more
doaj +1 more source
Identification of Epstein-Barr virus replication proteins in Burkitt’s lymphoma cells [PDF]
, 2015 The working model to describe the mechanisms used to replicate the cancer-associated virus Epstein-Barr virus (EBV) is partly derived from comparisons with other members of the Herpes virus family.
Almohammad, Rajei +8 more
core +2 more sources
Bone marrow-derived NGFR-positive dendritic cells regulate arterial remodeling
American Journal of Physiology-Cell PhysiologyWe propose a new concept of arterial remodeling after injury in which bone marrow-derived NGFR+ dendritic cells inhibit neointimal progression mediated by apoptosis. NGFR+ dendritic cells promote anti-inflammatory MRC1+ M2 macrophage accumulation and production of interleukin-10, inhibiting smooth muscle cell proliferation within the neointima.
Shinichiro Takashima +14 more
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Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1 [PDF]
, 2014 The Epstein-Barr virus (EBV) nuclear antigen 3 family of protein is critical for the EBV-induced primary B-cell growth transformation process. Using a yeast two-hybrid screen we identified 22 novel cellular partners of the EBNA3s. Most importantly, among
Bazot, Q +11 more
core +6 more sources
The functional role of NGFR in regulating chemosensitivity in nasopharyngeal carcinoma [PDF]
Annals of Oncology, 2018 Wei Gao +5 more
openalex +2 more sources
Current Oncology, 2022 Breast cancer represents the most common type of cancer and is the leading cause of death due to cancer among women. Thus, the prevention and early diagnosis of breast cancer is of primary urgency, as well as the development of new treatments able to ...
Francesco Bruno +5 more
doaj +1 more source
Relevance of different prior knowledge sources for inferring gene interaction networks [PDF]
, 2014 When inferring networks from high-throughput genomic data, one of the main challenges is the subsequent validation of these networks. In the best case scenario, the true network is partially known from previous research results published in structured ...
Bontempi, Gianluca +4 more
core +1 more source