A novel method for the isolation of subpopulations of rat adipose stem cells with different proliferation and osteogenic differentiation potentials [PDF]
Bone marrow has been the elected cell source of studies published so far concerning bone and cartilage tissue-engineering approaches. Recent studies indicate that adipose tissue presents significant advantages over bone marrow as a cell source for tissue
Ailhaud +63 more
core +1 more source
Expression of Low Affinity Nerve Growth Factor Receptor p75 in Classic Bladder Exstrophy
Successful primary closure of classic bladder exstrophy (BE) is crucial for development of bladder capacity and voided continence. It is universally agreed that an intensive pain management including the use of caudal epidural anesthesia is an essential ...
Martin Promm +9 more
doaj +1 more source
Insulin Reduces the Efficacy of Vemurafenib and Trametinib in Melanoma Cells
Marta Osrodek, 1 Michal Rozanski, 1, 2 Malgorzata Czyz 1 1Department of Molecular Biology of Cancer, Medical University of Lodz, Lodz, Poland; 2Laboratory of Transcriptional Regulation, Institute of Medical Biology, Polish Academy of Sciences, Lodz ...
Osrodek M, Rozanski M, Czyz M
doaj
Characteristics of gene expression in frozen shoulder
Background Severe frozen shoulder (FS) is often resistant to treatment and can thus result in long-term functional impairment. However, its etiology remains unknown. We hypothesized that gene expression of FS would vary by synovial location.
Hiroaki Nishimoto +4 more
doaj +1 more source
SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis [PDF]
Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage.
De Maeyer, Dries +3 more
core +2 more sources
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Nerve growth factor (NGF) receptors are evolutionary conserved molecules, and in mammals are considered necessary for ensuring the survival of cholinergic neurons.
Paolo de Girolamo +5 more
doaj +1 more source
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha +12 more
wiley +1 more source
Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice [PDF]
Background The next big challenge in human genetics is understanding the 98% of the genome that comprises non-coding DNA. Hidden in this DNA are sequences critical for gene regulation, and new experimental strategies are needed to understand the ...
Andrea J Korecki +16 more
core +1 more source
STING deficiency promotes motor recovery in mice following brachial plexus root avulsion
STING deficiency can increase the body weight, promote motor recovery, decrease MN death, inhibit pyroptosis and neuroinflammation, increase remyelination, and reduce the atrophy of the biceps brachii in mice with BPRA. Abstract Background Brachial plexus root avulsion (BPRA), a well‐known form of peripheral nerve injury, results in motor function loss
Yu Peng +4 more
wiley +1 more source

