Results 81 to 90 of about 86,862 (258)

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Cation–Anion Synergy Enables Uniform and Stable SAMs for High‐Efficiency Perovskite/TOPCon Tandem Solar Cells

Advanced Science, EarlyView.
A cation‐anion synergistic strategy is developed to enhance self‐assembled monolayer (SAM) adsorption using guanidinium thiocyanate (GuaSCN). Guanidinium (Gua⁺) suppresses micelle aggregation, while thiocyanate (SCN−) promotes phosphonic acid deprotonation and strengthens ionic bonding to the substrate.
Haofan Ma, Xin Li, Huan Li, Jianmin Guan, Luyao Zheng, Jun Wu, Ziyu He, Yunyun Yu, Jungan Wang, Jie Yang, Xinyu Zhang, Meili Zhang, Yuheng Zeng, Menglei Xu, Zhiqin Ying, Xi Yang, Jichun Ye   +16 more
wiley   +1 more source

Ion Crowding Effect in Unilaterally Downsized Perovskite Memristors

Advanced Science, EarlyView.
The downscaling of perovskite memristors incorporating monocrystalline nanoplates is accompanied by an ion crowding effect, which greatly enhances the local electric field in the vicinity of electrode. The highly controlled crowding of anions and vacancies results in anisotropic switching characteristics as well as unique morphology modification ...
Conghui Tan, Meiqi An, Weili Liu, Haotian Wang, Shuai Yang, Jing Li, Jianliang Li, Yingmin Luo, Chao Wang, Jiao Xu, Yaodan Chi, Yiming Yang   +11 more
wiley   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Large‐Aperture Polarization‐Independent Broadband Achromatic All‐Dielectric Metalens for Terahertz Focusing

Advanced Science, EarlyView.
A large‐aperture, high focusing efficiency and polarization‐independent THz single‐layer achromatic metalens is reported via discrete multi‐wavelength achromatic design and global optimization algorithm. The fabricated metalens exhibits a largest diameter of 2.21 cm, excellent achromatic performance, extremely high average focusing efficiency (> 46 ...
Xiaoqiang Jiang, Xu Chen, Zechuan Bin, Fu Tang, Min Hu, Manman Li, Baoli Yao   +6 more
wiley   +1 more source

Four-year follow-up from the phase 2 study TD-NICE: neoadjuvant treatment of tislelizumab combined with chemotherapy in resectable esophageal squamous cell carcinoma

BMC Cancer
Background The efficacy and safety of tislelizumab combined with chemotherapy as neoadjuvant therapy have been presented and evaluated in previously published TD-NICE study.
Yajie Mao, Zhiyuan Gao, Yichen Sun, Changjian Shao, Hongtao Duan, Xiaolong Yan   +5 more
doaj   +1 more source

胰岛素抵抗与非致残性缺血性脑血管病患者卒中复发之间的关系 Association between Insulin Resistance and Recurrent Stroke in Patients with Non-disabling Ischemic Cerebrovascular Events

Zhongguo cuzhong zazhi, 2019
目的 探讨不同胰岛素抵抗状态对无糖尿病史的非致残性缺血性脑血管病（non-disabling ischemic cerebrovascular events，NICE）患者卒中复发风险的影响。 方法 使用稳态模型胰岛素抵抗（homeostasis model assessment of insulin resistance，HOMA-I R）指数 对胰岛素抵抗进行评估。根据不同胰岛素抵抗状态，使用四分位法将无糖尿病史的NICE患者分为4 组。该研究的主要研究终点为90 d新发卒中（包括缺血性和出血性卒中）
陈玮琪，张国军，潘岳松，林金嬉，梁宪红，李上智，王伊龙，荆京，赵性泉，刘丽萍，王拥军
doaj   +1 more source

Surface Engineering on Transition Metal Dichalcogenides: In Situ Encapsulation of Metal–Organic Frameworks for Highly Humidity‐Resistant Gas Sensing at Room Temperature

Advanced Science, EarlyView.
2D UiO‐66‐NH2/MoS2 was fabricated via an aqueous synthesis method to in situ encapsulation of MoS2 with 2D UiO‐66‐NH2 MOF. The humidity‐resistant NO2 sensing of 2D UiO‐66‐NH2/MoS2 at room temperature was accordingly enhanced by MOF encapsulation layer, along with the selectivity and stability.
Junwei Zeng, Weicheng Jiao, You Wang, Ye Yuan, Xiaodong He, Yue Niu   +5 more
wiley   +1 more source

Recycled Piezoelectric Materials with Competitive Second‐Life Functional Properties

Advanced Electronic Materials, EarlyView.
The essential piezoelectric ceramics with heavy ecological footprints are not sufficiently recycled. This work demonstrates the feasibility of recycling different types of piezoelectric ceramics using different binders, where the terpolymer binder with relatively large permittivity facilitated superior retention of properties after recycling, promoting
Mohadeseh Tabeshfar, Sivagnana Sundaram Anandakrishnan, Yang Bai   +2 more
wiley   +1 more source

Topological Materials and Related Applications

Advanced Electronic Materials, EarlyView.
This review covers topological materials—including topological insulators, quantum valley Hall and quantum spin Hall insulators, and topological Weyl and Dirac semimetals—as well as their most recent advancements in fields such as spintronics, electronics, photonics, thermoelectrics, and catalysis.
Carlo Grazianetti, Roberto Mantovan, Emanuele Longo, Harold J. W. Zandvliet, Pantelis Bampoulis, Yu Pan, Fan Li, Xia Wang, Payton Downey, Alessandro Molle   +9 more
wiley   +1 more source