Results 231 to 240 of about 33,460,079 (338)

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Rethinking osteocyte models <i>in vitro</i>: the need for mineralised extracellular matrix and network architecture. [PDF]

Front Bioeng Biotechnol
Morenc M, Medeiros Savi F, Tits A, Buenzli PR, Weinkamer R, Fratzl P, Bock N.   +6 more
europepmc   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Projected Habitat Contraction and Distributional Shifts of the near Threatened Undulate Ray <i>Raja undulata</i> Under Climate Change. [PDF]

Biology (Basel)
Turan C, Soldo A.
europepmc   +1 more source

A PCA‐based modelling technique for predicting environmental suitability for organisms from presence records

, 2001
Mark P. Robertson, Neil Caithness, M. Villet   +2 more
semanticscholar   +1 more source

Niche conservatism and the invasive potential of the wild boar

Journal of Animal Ecology, 2017
L. Sales, B. Ribeiro, M. Hayward, A. Paglia, M. Passamani, R. Loyola   +5 more
semanticscholar   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

From Circuits to Symphonies: A Systems-Engineering Blueprint for Multimicrobial Synthetic Biology. [PDF]

Adv Sci (Weinh)
Fernández-Niño M, Wessjohann LA, Guillamón JM, Burgos-Toro D, Moriano-Gutiérrez S, Di Matteo G, Islam ZU, van van Tatenhove-Pel R, Rossetto Marcelino V, Ledesma-Amaro R.   +9 more
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source