Results 251 to 260 of about 1,062,757 (298)

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Methane Oxidation Potential and Niche Differentiation of Aerobic Methanotrophs in Coastal Mangrove Forest Soils along a 370 Km Long Coastline in Taiwan. [PDF]

Environ Sci Technol
Shiau YJ, Chen TK, Jia Z, Lin CW, Chiu CY.   +4 more
europepmc   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Ecological Niche Differentiation and Response to Climate Change of the African Endemic Family Myrothamnaceae. [PDF]

Plants (Basel)
Wan Q, Du S, Chen Y, Li F, Salah R, Njenga MN, Li J, Wang S.   +7 more
europepmc   +1 more source

Distinct lactate utilization strategies drive niche differentiation between two co-existing Megasphaera species in the rumen microbiome. [PDF]

ISME J
Strachan CR, Bowers CM, Kim BC, Movsesijan T, Neubauer V, Mueller AJ, Yu XA, Pereira FC, Nagl V, Faas J, Wagner M, Zebeli Q, Weimer PJ, Candry P, Polz MF, Lawson CE, Selberherr E.   +16 more
europepmc   +1 more source

Trophic Niche Differentiation in Two Sympatric Nuthatch Species (Sitta yunnanensis and Sitta nagaensis). [PDF]

Animals (Basel)
Guo Q, Lu X, Xie C, Zhang J, Xu X, Qian Y, Luo X, Duan Y.   +7 more
europepmc   +1 more source

Millimeter-scale niche differentiation of N-cycling microorganisms across the soil-water interface has implications for N2O emissions from wetlands. [PDF]

ISME J
Cai YJ, Zhang HY, Hu XR, Yang YC, Hazard C, Nicol GW, He JZ, Shen JP, He ZY, Zhang L, Zhang JH, Liu H, Zhang S, Chen Z.   +13 more
europepmc   +1 more source

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Ecological niche differentiation among anammox bacteria

Water Research, 2020
Anaerobic ammonium oxidizing (anammox) bacteria can directly convert ammonium and nitrite to nitrogen gas anaerobically and were responsible for a substantial part of the fixed nitrogen loss and re-oxidation of nitrite to nitrate in freshwater and marine ecosystems.
Satoshi Okabe
exaly   +3 more sources

Mechanical checkpoint regulates monocyte differentiation in fibrotic niches

Nature Materials, 2022
Myelofibrosis is a progressive bone marrow malignancy associated with monocytosis, and is believed to promote the pathological remodelling of the extracellular matrix. Here we show that the mechanical properties of myelofibrosis, namely the liquid-to-solid properties (viscoelasticity) of the bone marrow, contribute to aberrant differentiation of ...
Kyle H. Vining, Anna E. Marneth, Kwasi Adu-Berchie, Joshua M. Grolman, Christina M. Tringides, Yutong Liu, Waihay J. Wong, Olga Pozdnyakova, Mariano Severgnini, Alexander Stafford, Georg N. Duda, F. Stephen Hodi, Ann Mullally, Kai W. Wucherpfennig, David J. Mooney   +14 more
openaire   +4 more sources