Results 31 to 40 of about 1,062,757 (298)

Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses

Journal of Experimental & Clinical Cancer Research, 2022
Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma in which microenvironmental (niche) factors promote PDAC progression.
Tomohiko Shinkawa, Kenoki Ohuchida, Yuki Mochida, Kukiko Sakihama, Chika Iwamoto, Toshiya Abe, Noboru Ideno, Yusuke Mizuuchi, Koji Shindo, Naoki Ikenaga, Taiki Moriyama, Kohei Nakata, Yoshinao Oda, Masafumi Nakamura   +13 more
doaj   +1 more source

Niche differentiation is spatially and temporally regulated in the rhizosphere [PDF]

The ISME Journal, 2019
Abstract The rhizosphere is a hotspot for microbial C transformations, and the origin of root polysaccharides and polymeric carbohydrates that are important precursors to soil organic matter. However, the ecological mechanisms that underpin rhizosphere carbohydrate depolymerization are poorly understood. Using
Erin E Nuccio, Evan Starr, Ulas Karaoz, Eoin L Brodie, Jizhong Zhou, Susannah G Tringe, Rex R Malmstrom, Tanja Woyke, Jillian F Banfield, Mary K Firestone, Jennifer Pett-Ridge   +10 more
openaire   +4 more sources

Tracing early stages of species differentiation: Ecological, morphological and genetic divergence of Galapagos sea lion populations [PDF]

, 2008
Background: Oceans are high gene flow environments that are traditionally believed to hamper the build-up of genetic divergence. Despite this, divergence appears to occur occasionally at surprisingly small scales.
Brunner Sylvia, Sandie Salazar, Tautz, D. ; https://orcid.org/, Harrod, C., Tautz, D., Salazar, S., Sylvia Brunner, Wolf, Jochen B. W., Wolf, J.B.W., Harrod Chris, Wolf, J., Trillmich, Fritz ; https://orcid.org/, Trillmich Fritz, Trillmich, F., Tautz Diethard, Salazar, Sandie, Fritz Trillmich, Diethard Tautz, Wolf Jochen BW, Harrod, Chris, Brunner, Sylvia, Trillmich, Fritz, Chris Harrod, Brunner, S., Salazar Sandie, Jochen BW Wolf, Tautz, Diethard   +26 more
core   +1 more source

Non-cell-autonomous regulation of testicular stem cell niche homeostasis by the 20S proteasome core particle through cell adhesion and cyclin proteins [PDF]

Open Biology
The Drosophila stem cell niche harbours two principal stem cell populations: germline stem cells (GSCs) and cyst stem cells (CySCs), whose self-renewal and differentiation are stringently governed by niche-derived regulatory factors.
Jiaxin Li, Chenyu Wang, Weiyi Qian, Lei He, Qiuru Huang, Junwei Zhao, Ziyu Cao, Yuqi Huang, Yanting Wang, Xinda Wang, Yuwen Du, Xinyang Li, Guyue Zhu, Youran Li, Jun Yu, Xiaofang Tan, Zhiran Li   +16 more
doaj   +1 more source

An introduction to niche construction theory [PDF]

, 2016
Niche construction refers to the modification of selective environments by organisms. Theoretical and empirical studies of niche construction are increasing in importance as foci in evolutionary ecology.
Matthews, Blake, Laland, Kevin Neville, Blake Matthews, Marcus W. Feldman, Kevin Laland, Feldman, Marcus W.   +5 more
core   +1 more source

Hematopoietic Stem Cell Niche During Homeostasis, Malignancy, and Bone Marrow Transplantation

Frontiers in Cell and Developmental Biology, 2021
Self-renewal and multidirectional differentiation of hematopoietic stem cells (HSCs) are strictly regulated by numerous cellular components and cytokines in the bone marrow (BM) microenvironment.
Yan Man, Yan Man, Xiangmei Yao, Xiangmei Yao, Tonghua Yang, Tonghua Yang, Yajie Wang, Yajie Wang   +7 more
doaj   +1 more source

The Role of Lymphatic Niches in T Cell Differentiation

Molecules and Cells, 2016
Long-term immunity to many viral and bacterial pathogens requires CD8(+) memory T cell development, and the induction of long-lasting CD8(+) memory T cells from a naïve, undifferentiated state is a major goal of vaccine design. Formation of the memory CD8(+) T cell compartment is highly dependent on the early activation cues received by naïve CD8(+) T ...
Capece, Tara, Kim, Minsoo
openaire   +3 more sources

Shifts in climate foster exceptional opportunities for species radiation: the case of South african geraniums. [PDF]

PLoS ONE, 2013
Climate change is often assumed to be a major driver of biodiversity loss. However, it can also set the stage for novel diversification in lineages with the evolutionary ability to colonize new environments.
Hugo I Martínez-Cabrera, Pedro R Peres-Neto   +1 more
doaj   +1 more source

A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation [PDF]

Developmental Cell, 2020
The interplay between pancreatic epithelium and the surrounding microenvironment is pivotal for pancreas formation and differentiation as well as adult organ homeostasis. The mesenchyme is the main component of the embryonic pancreatic microenvironment, yet its cellular identity is broadly defined, and whether it comprises functionally distinct cell ...
Cozzitorto, Corinna, Mueller, Laura, Ruzittu, Silvia, Mah, Nancy, Willnow, David, Darrigrand, Jean-Francois, Wilson, Heather, Khosravinia, Daniel, Mahmoud, Amir-Ala, Risolino, Maurizio, Selleri, Licia, Spagnoli, Francesca   +11 more
openaire   +5 more sources

Endemicity and climatic niche differentiation in three marine ciliated protists [PDF]

, 2018
The biogeographic pattern of single‐celled eukaryotes (protists), including ciliates, is poorly understood. Most marine species are believed to have a relatively high dispersal potential, such that both globally distributed and geographically isolated ...
Richard A. J. Williams, Williams, Richard, Clamp, John, Owens, Hannah L, Hannah L. Owens, Mercedes Martín‐Cereceda, Peterson, A Townsend, John Clamp, Martin-Cereceda, Mercedes, A. Townsend Peterson, Alan Warren, Warren, Alan   +11 more
core   +1 more source