Results 71 to 80 of about 139,272 (299)

How self-regulation, the storage effect and their interaction contribute to coexistence in stochastic and seasonal environments [PDF]

, 2019
Explaining coexistence in species-rich communities of primary producers remains a challenge for ecologists because of their likely competition for shared resources.
Barraquand, Frederic, Picoche, Coralie
core   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Integrative Approaches for Precise Identification and Range Delimitation of the Three Most Common European Leiopus species (Coleoptera, Cerambycidae)

Zoodiversity
Leiopus nebulosus (Linnaeus, 1758), L. linnei Wallin, Nylander & Kvamme, 2009 and L. femoratus Fairmaire, 1859 are the three most common European species of the long-horn beetle genus Leiopus Audinet-Serville, 1835.
A. Zamoroka
doaj   +1 more source

Marginalization of end-use technologies in energy innovation for climate protection [PDF]

, 2012
Mitigating climate change requires directed innovation efforts to develop and deploy energy technologies. Innovation activities are directed towards the outcome of climate protection by public institutions, policies and resources that in turn shape ...
A Bergek, A Grubler, A Grubler, A Grubler, A Grubler, A Kitous, A Lovins, A McDonald, A Torvanger, AL D'Agostino, B Carlsson, B Kiss, B-A Lundvall, BA Sandén, BK Sovacool, BS Fisher, C Edquist, C Freeman, C Freeman, C Greenwood, C Wilson, C-O Wene, D Archibugi, D McCollum, D Mowery, D Van Vuuren, D Ürge-Vorsatz, DA Irwin, E Moe, EM Rogers, ES Rubin, F Alkemade, FW Geels, G Dosi, G Luderer, G Unruh, G Verbong, GF Nemet, GF Nemet, GF Nemet, I Galiana, J Meadowcroft, J Sathaye, J Schot, JD Van den Wall Bake, JG Koomey, JM Deutch, JS Norgard, K Astrand, K Riahi, K Riahi, KS Gallagher, KS Gallagher, L Kamp, M Amann, M Heymann, M Levine, M Lynas, M Weiss, MI Hoffert, MI Hoffert, MP Hekkert, MP Hekkert, N Hughes, N Lutsey, N Nakicenovic, NP Myhrvold, O Edenhofer, O Edenhofer, O Edenhofer, PD Maycock, PL Joskow, R Fouquet, R Garud, R Marlay, R Murphy, RR Nelson, RW Fri, S Jacobsson, S Pacala, S Teske, T Hanaoka, UC Colpier, V Bush, WJ Abernathy, Y Iwafune, Z Griliches   +86 more
core   +1 more source

Do selfing species have greater niche breadth? Support from ecological niche modeling

Evolution, 2019
We explore the relationship between plant mating system (selfing or outcrossing) and niche breadth to gain new insights into processes that drive species distributions. Using a comparative approach with highly selfing versus highly outcrossing sister species, we test the extent to which: (1) species pairs have evolved significant niche divergence and ...
Alannie-Grace, Grant, Susan, Kalisz
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Global Habitat Suitability and Ecological Niche Separation in the Phylum Placozoa. [PDF]

PLoS ONE, 2015
The enigmatic placozoans, which hold a key position in the metazoan Tree of Life, have attracted substantial attention in many areas of biological and biomedical research.
Omid Paknia, Bernd Schierwater
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Context-Choice Model of Niche Entrepreneurship

Entrepreneurship Theory and Practice, 2020
Entrepreneurship research has gravitated towards a singular focus on the Silicon Valley model as the standard model of entrepreneurship. By contrast, some entrepreneurship scholars have more recently suggested embracing entrepreneurship as diverse and colorful.
David B. Audretsch, Erik E. Lehmann, Julian Schenkenhofer   +2 more
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source