Results 81 to 90 of about 139,272 (299)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Evaluating the ecological realism of plant species distribution models with ecological indicator values [PDF]

, 2020
Species distribution models (SDMs) are routinely applied to assess current as well as future species distributions, for example to assess impacts of future environmental change on biodiversity or to underpin conservation planning.
Ellenberg H., Ellenberg H., Fagerli H., Fourcade Y., Frank D., Hazeu G. W., Hennekens S. M., Hill M. O., Janssen J. A. M., Landolt E., Pignatti S., Schaminée J. H. J., Schaminée J. H. J., Schaminée J. H. J., Schaminée J. H. J., Settele J., Thuiller W.   +16 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Effects of Green-Synthesised Copper Oxide–Zinc Oxide Hybrid Nanoparticles on Antifungal Activity and Phytotoxicity of Aflatoxin B1 in Maize (Zea mays L.) Seed Germination

Agronomy
Maize contamination with aflatoxin B1 (AFB1) is of significance on a global scale due to its major contribution to food security. It is very probable that substantial amounts of AFB1 may be absorbed by germinating seeds grown in contaminated soil and ...
Simangele C. Ngwenya, Nkanyiso J. Sithole, Doctor M. N. Mthiyane, Martha C. Jobe, Olubukola O. Babalola, Ayansina S. Ayangbenro, Mulunda Mwanza, Damian C. Onwudiwe, Khosi Ramachela   +8 more
doaj   +1 more source

Experimental validation of multiphase flow models and testing of multiphase flow meters: A critical review of flow loops worldwide [PDF]

, 2016
Around the world, research into multiphase flow is performed by scientists with hugely diverse backgrounds: physicists, mathematicians and engineers from mechanical, nuclear, chemical, civil, petroleum, environmental and aerospace disciplines ...
Bello, O. O., Falcone, Gioia, Teodoriu, C.   +2 more
core   +1 more source

Ecological niche modelling

Current Biology
One of the central research questions in ecology and biogeography revolves around understanding the spatial distribution patterns of organisms, the factors influencing species abundance, and why in certain areas there are more species or individuals than in others.
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The evolution of carrying capacity in constrained and expanding tumour cell populations

, 2015
Cancer cells are known to modify their micro-environment such that it can sustain a larger population, or, in ecological terms, they construct a niche which increases the carrying capacity of the population.
Anderson, Alexander R. A., Gerlee, Philip   +1 more
core   +1 more source