Results 131 to 140 of about 519,778 (295)

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

The relationship between phylogeny, range size, niche breadth and niche overlap in European orchids (Orchidaceae) [PDF]

Aim: Understanding the various factors that contribute to the distribution and geographical ranges of plant and animal species has been a central issue in ecology, evolution and biogeography for more than two centuries.
Merckx, V.S.F.T., Evans, A., De Coensel, B., Wang, D., Jacquemyn, H.   +4 more
core   +1 more source

Niche enlargement as a consequence of co-existence: a case study

Brazilian Journal of Biology
Spatio-temporal changes in the diet, niche breadth and niche overlap of two species of Characidium from three different sites along a Neotropical coastal stream were studied during a dry and rainy season.
R. Mazzoni, PS. Marques, CF. Rezende, R. Iglesias-Rios   +3 more
doaj   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

R Script for estimation of niche region and testing for niche overlap in nicheROVER

, 2019
R Script for estimation of niche region and testing for niche overlap in ...
Stacey D. Smith (3262935), Julia Dupin (6319919)   +1 more
core   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Measuring ecological niche overlap from occurrence and spatial environmental data

, 2011
1. Aim - Concerns over how global change will influence species distributions, in conjunction with increased emphasis on understanding niche dynamics in evolutionary and community contexts, highlight the growing need for robust methods to quantify niche ...
Fitzpatrick, M.C., Christophe Randin, Nigel G. Yoccoz, Zimmermann, N.E., Yoccoz, N. G., Matthew C. Fitzpatrick, Petitpierre, B., Wilfried Thuiller, Fitzpatrick, M. C., Pellissier, L., Blaise Petitpierre, Graham, C.H., Fortin, M.J., Broennimann, Olivier, Peter B. Pearman, Pearman, P.B., Catherine H. Graham, Antoine Guisan, Olivier Broennimann, Randin, C., Randin, C.R., Marie-Josée Fortin, Pearman, P. B., Fortin, M.-J., Thuiller, W., Guisan, A., Niklaus E. Zimmermann, Graham, C. H., Zimmermann, N. E., Yoccoz, N.G., Broennimann, O., Loïc Pellissier   +31 more
core   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Metagenomic analysis of ecological niche overlap and community collapse in microbiome dynamics. [PDF]

Front Microbiol, 2023
Fujita H, Ushio M, Suzuki K, Abe MS, Yamamichi M, Okazaki Y, Canarini A, Hayashi I, Fukushima K, Fukuda S, Kiers ET, Toju H.   +11 more
europepmc   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source