Results 31 to 40 of about 482,662 (301)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Evaluation of worker exposures to nickel during the plating, machining, and facrication [sic] of nickel plated metal [PDF]
, 2001 Plan BThe goal of this study was to assist a company involved in nickel plating, machining, and fabricating of nickel plated metal, in evaluating and reducing its employee exposure to nickel concentrations in the affected work areas.
Keyes, Jeff
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International Journal of Coal Science & Technology, 2022 The occurrence of disasters in deep mining engineering has been confirmed to be closely related to the external dynamic disturbances and geological discontinuities. Thus, a combined finite-element method was employed to simulate the failure process of an
Fan Feng +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Nickel-Catalyzed Reductive [2+2] Cycloaddition of Alkynes
, 2018 The nickel-catalyzed synthesis of tetrasubstituted cyclobutenes from alkynes is reported. This transformation is uniquely promoted by the use of a primary aminophosphine, an unusual ligand in nickel catalysis.
Santiago Cañellas (3684409) +2 more
core +4 more sources
Горные науки и технологииDeclining ore grades at the Norilsk deposits are accompanied by increasing variability in the quality of mined ore and deterioration in the quality of saleable products.
N. A. Turtygina +3 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Urbe, 2021 El Foro Abierto es el espacio público de la Universidad de Concepción (región del Biobío, Chile) con mayor significación ciudadana. Al estar protegido por su calidad de Monumento Histórico, sus intervenciones deben enmarcarse en guías institucionales ...
Meliza Nickel
doaj +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Molecular mechanisms of nickel carcinogenesis: nickel binding to histone H4 and Cap43 protein [PDF]
, 2005 The carcinogenicity of nickel compounds has been confirmed and corroborated by numerous epidemiological studies in humans and carcinogenesis bioassays in animals.
Medici, Serenella +2 more
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