Results 31 to 40 of about 607 (217)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Study of the solid phase extraction and spectrophotometric determination of nickel using 5-(4′-chlorophenylazo)-6-hydroxypyrimidine-2,4-dione in environmental samples

Journal of Saudi Chemical Society, 2011
A rapid, sensitive and selective method for the determination of nickel based on the rapid reaction of nickel(II) with 5-(4′-chlorophenylazo)-6-hydroxypyrimidine-2,4-dione (CPAHPD) and the solid phase extraction of the Ni(II)–CPAHPD complex with C18 ...
Alaa S. Amin, Amirah S. AL-Attas
doaj   +1 more source

Crystal structure of dibromidotetrakis(propan-2-ol-κO)nickel(II)

Acta Crystallographica Section E: Crystallographic Communications, 2015
The asymmetric unit of the mononuclear title complex, [NiBr2(C3H8O)4], comprises a NiII cation located on a centre of inversion, one Br− anion and two propan-2-ol ligands. The NiII cation exhibits a distorted trans-Br2O4 environment.
Yaokang Lv, Mingxian Liu, Lvlv Ji, Cheng Zhang, Mi Ouyang   +4 more
doaj   +1 more source

Cis versus trans arrangement of dithiocarbazate ligands in bis-chelated Ni and Cu complexes

Acta Crystallographica Section E: Crystallographic Communications, 2020
The structures are described of two bis-chelated metal complexes of nickel(II) and copper(II) with S-n-hexyl 3-(1-phenylethylidene)dithiocarbazate Schiff bases in a cis configuration, namely, bis[S-n-hexyl 3-(1-phenylethylidene)dithiocarbazato-κ2N3,S ...
Khurshida Begum, Sabina Begum, Chanmiya Sheikh, Ryuta Miyatake, Ennio Zangrando   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Synthesis and Characterization of ONO Pincer Ligand Precursors and Metal Complexes with Ethyl, Isopropyl and Tert-Butyl Wingtip Groups

Crystals
We have synthesized novel cobalt(II) and nickel(II) pincer ligand complexes containing novel tridentate ligand precursors that coordinate via oxygen, nitrogen, and oxygen donor atoms.
John R. Miecznikowski, Olivier J. C. Nicaise, Brandon Q. Mercado, Abigail J. Araujo, Natalia R. Bertolotti, Samantha L. Erickson, Joseph P. Trucchio, Michael J. Corbett, Connor J. Padover, Stephanie L. Coulombe, Audrey J. Wheeler, Isaac P. Ouellette   +11 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Copper(II), Nickel(II) and Zinc(II) Complexes of Peptide Fragments of Tau Protein

Molecules
Copper(II), nickel(II) and zinc(II) complexes of various peptide fragments of tau protein were studied by potentiometric and spectroscopic techniques. All peptides contained one histidyl residue and represented the sequences of tau(91–97) (Ac-AQPHTEI-NH2)
Zsuzsa Kastal, Adrienn Balabán, Szilvia Vida, Csilla Kállay, Lajos Nagy, Katalin Várnagy, Imre Sóvágó   +6 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source