Results 1 to 10 of about 5,118,016 (66)
Antioxidants, 2023 Salicylic acid (SA) and proline exhibit protective effects against a wide range of stresses. However, the combined impact of SA and proline on rice under drought stress is still unknown.
Salicylic Acid +9 more
semanticscholar +1 more source
DNAzymes: Expanding the Potential of Nucleic Acid Therapeutics
Nucleic Acid Therapeutics, 2023 Nucleic acids drugs have been proven in the clinic as a powerful modality to treat inherited and acquired diseases. However, key challenges including drug stability, renal clearance, cellular uptake, and movement across biological barriers (foremost the ...
Leon M Larcher +4 more
semanticscholar +1 more source
Reprogramming of fatty acid metabolism in cancer
British Journal of Cancer, 2019 A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival.
Nikos Koundouros, G. Poulogiannis
semanticscholar +1 more source
Bile acid metabolites control Th17 and Treg cell differentiation
bioRxiv, 2018 Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated transformation to generate a large pool of bioactive molecules. Although bile acids are known to affect host metabolism, cancer progression and innate immunity, it is ...
Saiyu Hang +19 more
semanticscholar +1 more source
An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
Nutrients, 2016 In the past three decades, total fat and saturated fat intake as a percentage of total calories has continuously decreased in Western diets, while the intake of omega-6 fatty acid increased and the omega-3 fatty acid decreased, resulting in a large ...
A. Simopoulos
semanticscholar +1 more source
Predicting the Functional Effect of Amino Acid Substitutions and Indels
PLoS ONE, 2012 As next-generation sequencing projects generate massive genome-wide sequence variation data, bioinformatics tools are being developed to provide computational predictions on the functional effects of sequence variations and narrow down the search of ...
Yongwook Choi +4 more
semanticscholar +1 more source
Nucleic Acid Therapeutics, 2023 Antisense oligonucleotide (AON)-mediated exon skipping is a promising therapeutic approach for Duchenne muscular dystrophy (DMD) patients to restore dystrophin expression by reframing the disrupted open reading frame of the DMD transcript.
S. Engelbeen +9 more
semanticscholar +1 more source
Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier.
Polymers, 2011 In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications.
Hirenkumar K. Makadia, S. Siegel
semanticscholar +1 more source
Predicting deleterious amino acid substitutions.
Genome Research, 2001 Many missense substitutions are identified in single nucleotide polymorphism (SNP) data and large-scale random mutagenesis projects. Each amino acid substitution potentially affects protein function. We have constructed a tool that uses sequence homology
P. Ng, S. Henikoff
semanticscholar +1 more source
Journal of Experimental Medicine, 2007 Foxp3+ regulatory T (T reg) cells play a key role in controlling immune pathological re actions. Many develop their regulatory activity in the thymus, but there is also evidence for development of Foxp3+ T reg cells from naive precursors in the periphery.
J. Coombes +6 more
semanticscholar +1 more source