Results 51 to 60 of about 36,998 (271)
Advanced Science, EarlyView.This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan +10 more
wiley +1 more source
Acid‐ and Nucleophile‐Gated Photoisomerization of Phosphaindirubin
Angewandte Chemie, EarlyView.Triply gated isomerization: In polar solvents, a phosphorus‐containing indirubin photoswitch undergoes visible‐light‐driven Z→E isomerization only when protonated, and reverts thermally via nucleophile‐catalyzed back‐isomerization. This three‐way control by light, acid, and nucleophile enables reversible photoisomerization.
Jacob Jan van der Wal +8 more
wiley +2 more sources
Recollections of schoolteachers' nicknames
Names, 2004 An investigation of schoolteachers’ nicknames recalled by a sample of 103 students showed that the majority of nicknames were negative in tone and directed mostly at disliked and unpopular teachers.
W. Ray Crozier
doaj +1 more source
Collective Nicknames of the Perm Region Residents
Вопросы ономастики, 2023 The article is the first part of the collaborative work studying Russian collective nicknames of the modern Perm Region. It aims to systematize the materials, analyze regional historiographical heritage and the sources of the studied units, explore the ...
Irina I. Rusinova, Alexander V. Chernykh
doaj +1 more source
USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer
Advanced Science, EarlyView.USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley +2 more sources
The Malditas, The Filipinas, and The Azkals
NamesNicknames in sports can serve a wide range of social and semantic functions. Assigning nicknames to athletes and teams can allow fans to identify with them.
Satwinder Rehal, Inez Z. Ponce de Leon
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Nicknames and Women Professional Baseball Players
Names, 1990 Although women in the general population tend to have fewer nicknames than men, women baseball players in the All-American Girls Baseball League, 1943–1954, were as likely as male baseball players to have public nicknames. This high percentage may be the
Brenda S. Wilson, James K. Skipper
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Advanced Science, EarlyView.This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.Multi‐crystal X‐ray diffraction (MCXRD) methods allow accurate structural characterisation with crystals too small for single‐crystal X‐ray diffraction and too large for electron diffraction, as demonstrated here for metal‐organic frameworks, and alleviate the radiation‐induced chemical changes that can result from using high‐intensity X‐ray sources to
Joshua P. Smith +9 more
wiley +2 more sources